62288-65-7

Upstream product

• 613-91-2 acetophenone oxime 
• 407-25-0 trifluoroacetic anhydride 
• 13280-20-1 1-phenylethanimine 
• 32366-25-9 1-azidoethylbenzene 
• 585-71-7 (1-bromoethyl)benzne 
• 98-86-2 acetophenone 

Downstream Products

• 2354-91-8 N-<(R)-(+)-α-phenylethyl>-2,2,2-trifluoroacetamide 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 2354-91-8 (S)-2,2,2-trifluoro-(α-methylbenzyl)acetamide 

Relevant academic research and scientific papers

CATALYTIC PREPARATION OF ENAMIDES FROM ALKYL AZIDES AND ACYL DONORS

The present invention relates to a method to synthesize an enamide compound by generating imine which does not have a substituent group bonded to the nitrogen from an organic azide compound and conducting a reaction of the same with acyl doner. By using t

Exploiting the Nucleophilicity of N-H Imines: Synthesis of Enamides from Alkyl Azides and Acid Anhydrides

The nucleophilicity of N-unsubstituted imines, which were generated from alkyl azides by a ruthenium-catalyzed reaction, was investigated in the reaction with acid anhydrides. The initial products were N-acylimines, which isomerized to the corresponding e

Efficient synthesis of chiral phenethylamines: preparation, asymmetric hydrogenation, and mild deprotection of ene-trifluoroacetamides

A mild and efficient route to enantioenriched aryl alkyl amines from ketones has been developed. The first successful synthesis and asymmetric hydrogenation of ene-trifluoroamides from oximes gave highly enantioenriched trifluoroacetamides (94-98% ee). The corresponding phenethyl amides are liberated under mild conditions (K2CO3, MeOH/H2O). In addition, a new application of Josiphos ligands toward the asymmetric hydrogenation of both ene-acetamides and ene-trifluoroacetamides was discovered.