6232-83-3Relevant academic research and scientific papers
Synthesis and biological screening of 3-(N-substituted carboxamidomethylthio)-4-methyl-(4H)-1,2,4-triazoles
Khatale, Pravin N.,Shivkumar,Manikrao, Anil M.,Mahajan, Niranjan S.,Jawarkar, Rahul D.
, p. 349 - 354 (2013/09/24)
4-Methyltriazolin-5-thione was synthesized from 1-formyl-4-methyl-3- thiosemicarbazide. Different N-substituted chloroacetamides were prepared by reacting substituted amines with chloroacetyl chloride. Synthesized N-substituted chloroacetamides were condensed with 4-methyltriazolin-5-thione in basic medium to obtain various 3-(N-substituted carboxamidomethylthio)-4- methyl-(4H)-1,2,4-triazoles. The structures of the synthesized compounds were confirmed by IR, 1H NMR, Mass spectra and elemental analysis. All the compounds were screened for their analgesic and antiinflammatory activity. In the present series compounds 6b and 6f showed noteworthy analgesic and antiinflammatory activity.
