62353-77-9

Usage

Uses

Used in Pharmaceutical Research and Development:
3-Iodo-thiophene-2-carboxylic acid Methyl ester is employed as a building block in pharmaceutical research for the synthesis of various pharmaceutical compounds. Its unique structure and functional groups contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemicals:
In the agrochemical industry, 3-Iodo-thiophene-2-carboxylic acid Methyl ester is used as a key intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its incorporation into these products enhances their effectiveness in controlling pests and weeds, thereby improving crop yields and quality.
Used in Dye Production:
3-Iodo-thiophene-2-carboxylic acid Methyl ester is utilized as an intermediate in the production of dyes, particularly those with specific color properties and stability. Its presence in the dye synthesis process contributes to the creation of dyes with improved performance characteristics, such as colorfastness and resistance to fading.
Used in Specialty Chemicals:
In the specialty chemicals industry, 3-Iodo-thiophene-2-carboxylic acid Methyl ester is employed as an intermediate for the synthesis of various specialty chemicals with unique properties and applications. These chemicals may be used in a range of industries, including plastics, coatings, and textiles, where their specific characteristics provide added value and performance.
Safety Precautions:
Due to the potential hazards associated with 3-Iodo-thiophene-2-carboxylic acid Methyl ester, it is essential to handle and store the compound properly. It should be used in a well-ventilated area, and appropriate protective equipment, such as gloves, goggles, and masks, should be worn to minimize exposure and ensure the safety of individuals working with the compound.

Upstream product

• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 27452-17-1 6-bromo-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene 
• 60166-84-9 3-iodo-thiophene-2-carboxylic acid 
• 527-72-0 2-thiophenylcarboxylic acid 
• 67-56-1 methanol 
• 75427-00-8 3-iodo-2-thiophenecarbonyl chloride 

Downstream Products

• 91902-81-7 3-(4-methylphenyl)-2-thiophenecarboxylic acid methyl ester 
• 1383385-41-8 C₂₉H₄₁NO₃S 
• 1383384-24-4 5-(3,3-dimethyl-but-1-ynyl)-3-(4-(4-methyl-cyclohexyl)-1-(tetrahydro-furan-3-ylmethyl)-1,2,5,6-tetrahydro-pyridin-3-yl)-thiophene-2-carboxylic acid 
• 1383383-11-6 5-iodo-3-[1-methyl-5-(4-methyl-cyclohexyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-thiophene-2-carboxylic acid 
• 1383385-78-1 C₂₄H₃₃NO₂S 
• 1383385-77-0 C₁₈H₂₄INO₂S 
• 1383385-76-9 C₁₉H₂₆INO₂S 
• 1383385-75-8 C₁₉H₂₇NO₂S 
• 1383385-74-7 C₁₉H₂₄NO₂S⁽¹⁺⁾*I^(1-) 
• 1383385-73-6 C₁₈H₂₁NO₂S 
• 1383384-18-6 5-(3,3-dimethyl-but-1-ynyl)-3-[4-(4-methyl-cyclohexyl)-1,2,5,6-tetrahydro-pyridin-3-yl]-thiophene-2-carboxylic acid 
• 1383385-38-3 C₂₂H₃₃IN₂O₂S 
• 1383384-08-4 3-[1-methyl-5-(4-methyl-cyclohexyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-5-{4-[(thiazole-4-carbonyl)-amino]-phenyl}-thiophene-2-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester 
• 1383384-07-3 ethyl 3-(1-methyl-5-(4-methyl-cyclohexyl)-1,2,3,6-tetrahydro-pyridin-4-yl)-5-(4-((thiazole-4-carbonyl)-amino)-phenyl)-thiophene-2-carboxylate 

Relevant academic research and scientific papers

Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N-Halosuccinimide

A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO2) and N-halosuccinimide (NXS) in DMF at room temperature under metal- and acid-free condition is described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide.

INHIBITORS OF HEPATITIS C VIRUS POLYMERASE

The present invention provides, among other things, compounds represented by the general Formula (I) and pharmaceutically acceptable salts thereof, wherein X, Y, R1A, R1B, R2, and R3 are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.

Retinoic acid X-receptor ligands

Compounds of formula (I) wherein R 1 -R 7, R 10, X and the dotted bond have the meaning given in the specification, bind selectively to retinoid RXR receptors and are useful as antiproliferative agents for dermatological and oncological indications.

Strategy for a seven-membered ring closure with bicyclic framework

Radical-induced cyclisations to form 7-membered rings with bicyclic framework were achieved by tributyltin hydride (TBTH) and α,α′-azobis(isobutyronitrile) (AIBN).

THE BEHAVIOUR OF VICINAL ALKYL AMINOTHIOPHENECARBOXYLATES IN THE SANDMEYER AND SCHIEMANN REACTIONS

The diazotization of vicinal alkyl aminothiophenecarboxylates has been studied. 3-Amino compounds gave clear diazonium salts which yielded the expected halo derivatives in the Sandmeyer and Schiemann conditions.However, 2-amino compounds yielded self-coupling products.