62353-77-9

Basic information

• Product Name: 3-Iodo-thiophene-2-carboxylic acid Methyl ester
• Synonyms: 3-Iodo-thiophene-2-carboxylic acid Methyl ester
• CAS NO: 62353-77-9
• Molecular Formula: C₆H₅IO₂S
• Molecular Weight: 268.07217
• EINECS: -0
• Mol File: 62353-77-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 51～52℃
• Boiling Point: 160-161 °C(Press: 12 Torr)
• Appearance: /
• Density: 1.930±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 3-Iodo-thiophene-2-carboxylic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Iodo-thiophene-2-carboxylic acid Methyl ester(62353-77-9)
• EPA Substance Registry System: 3-Iodo-thiophene-2-carboxylic acid Methyl ester(62353-77-9)

Safety Data

• Hazardous Substances Data: 62353-77-9(Hazardous Substances Data)

Usage

General Description

3-Iodo-thiophene-2-carboxylic acid Methyl ester is a chemical compound with the molecular formula C7H7IO2S. It is a methyl ester derivative of 3-iodo-thiophene-2-carboxylic acid, which is a substituted heterocyclic compound containing a thiophene ring with an iodo group and a carboxylic acid functional group. This chemical is commonly used in organic synthesis and pharmaceutical research as a building block for various pharmaceutical compounds and agrochemicals. It is also used as an intermediate in the production of dyes and other specialty chemicals. The compound may present hazards if not handled and stored properly, and should be used in a well-ventilated area with appropriate protective equipment.

Upstream product

• 60166-84-9 3-iodo-thiophene-2-carboxylic acid 
• 27452-17-1 6-bromo-1,2,3,4-tetrahydro-1,1,4,4-tetramethylnaphthalene 
• 527-72-0 2-thiophenylcarboxylic acid 
• 67-56-1 methanol 
• 75427-00-8 3-iodo-2-thiophenecarbonyl chloride 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 

Downstream Products

• 81452-54-2 methyl 3-methylthiophene-2-carboxylate 
• 60166-84-9 3-iodo-thiophene-2-carboxylic acid 
• 91902-81-7 3-(4-methylphenyl)-2-thiophenecarboxylic acid methyl ester 
• 203112-86-1 6-(3-iodo-2-(methyl)thiophene)-2-cyclohexen-1-one 
• 21676-89-1 methyl 3-phenylthiophene-2-carboxylate 
• 10341-88-5 3-phenyl-thiophen-2-carboxylic acid 
• 1383385-72-5 C₁₈H₁₉NO₂S 
• 1383385-13-4 C₂₈H₃₆N₂O₃S 
• 1383385-12-3 C₂₆H₃₄N₂O₂S 
• 1383385-11-2 C₃₁H₄₂N₂O₄S 
• 1383383-33-2 5-(3-acetylamino-phenyl)-3-[1-ethyl-5-(4-methyl-cyclohexyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-thiophene-2-carboxylic acid 
• 1383383-30-9 5-(3-amino-3-methyl-but-1-ynyl)-3-(1-ethyl-5-(4-methyl-cyclohexyl)-1,2,3,6-tetrahydro-pyridin-4-yl)-thiophene-2-carboxylic acid 
• 1383385-09-8 C₂₅H₃₆N₂O₂S 
• 1383383-27-4 5-(4-acetylamino-phenyl)-3-[1-ethyl-5-(4-methyl-cyclohexyl)-1,2,3,6-tetrahydro-pyridin-4-yl]-thiophene-2-carboxylic acid 

Relevant articles and documents

Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N-Halosuccinimide

A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO2) and N-halosuccinimide (NXS) in DMF at room temperature under metal- and acid-free condition is described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide.

Strategy for a seven-membered ring closure with bicyclic framework

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THE BEHAVIOUR OF VICINAL ALKYL AMINOTHIOPHENECARBOXYLATES IN THE SANDMEYER AND SCHIEMANN REACTIONS

The diazotization of vicinal alkyl aminothiophenecarboxylates has been studied. 3-Amino compounds gave clear diazonium salts which yielded the expected halo derivatives in the Sandmeyer and Schiemann conditions.However, 2-amino compounds yielded self-coupling products.