62360-00-3Relevant academic research and scientific papers
Copper(I)-catalyzed solvolysis of gem-chlorofluoro- and gem-bromofluorocyclopropanes. Preparation of 2-fluoroallylic ethers, esters and alcohols
Novikov, Maxim A.,Volchkov, Nikolai V.,Lipkind, Maria B.,Nefedov, Oleg M.
supporting information, p. 131 - 143 (2015/10/05)
Copper(I)-catalyzed solvolysis of gem-chlorofluoro- and gem-bromofluorocyclopropanes in MeOH, NaOAc/AcOH, NaOAc/DMF, HCO2Na/HCO2H or water/dioxane affords 2-fluoroallylic ethers, esters or alcohols in moderate to excellent yields. Th
Direct fluorination of styrenes
Shao, Qian,Huang, Yong
supporting information, p. 6584 - 6586 (2015/04/14)
We have developed a practical method to synthesize fluorostyrene compounds. A mild and regioselective mono-fluorination reaction occurred smoothly for various di- and trisubstituted styrenes in the presence of RuCl3 and N-fluorobenzenesulfonimide (NFSI). A tandem alkyne hydroarylation-olefin fluorination reaction was also developed using an Au catalyst.
Iridium-catalyzed asymmetric hydrogenation of fluorinated olefins using N,P-ligands: A struggle with hydrogenolysis and selectivity
Engman, Mattias,Diesen, Jarle S.,Paptchikhine, Alexander,Andersson, Pher G.
, p. 4536 - 4537 (2007/10/03)
To broaden the substrate scope of asymmetric iridium-catalyzed hydrogenation, fluorine-functionalized olefins were synthesized and hydrogenated with iridium complexes. Preliminary results showed high levels of fluorine elimination together with low selectivity. The loss of vinylic fluorine at first seemed difficult to handle, but further studies revealed that a catalyst with an azanorbornyl scaffold in the ligand gave more promising results. With this in mind, a new ligand was developed. This gave among the best results published to date for fluorine asymmetric hydrogenation, yielding high conversion and very high ee's with very little fluorine elimination. Further increasing the selectivity, the trials also revealed that tetrasubstituted fluorine-containing olefins can be hydrogenated with high ee's, despite that this class of compounds has usually shown low reactivity in this reaction type. Copyright
SOLVOLYSIS OF gem-DIHALOGENOCYCLOPROPANES IN THE PRESENCE OF SILVER SALTS
Molchanov, A. P.,Kostikov, R. R.
, p. 429 - 435 (2007/10/02)
The methanolysis and acetolysis of substituted gem-dibromo- and gem-bromofluorocyclopropanes in the presence of silver salts lead to the products from opening of the three-membered ring.Their ratio is determined by the charge distribution in the intermediate cation.When heated the obtained thermodynamically less stable isomers isomerize to the more stable isomers.
