624-86-2

Usage

Flammability and Explosibility

Flammable

InChI:InChI=1/C2H7NO/c1-2-4-3/h2-3H2,1H3

Upstream product

• 141-52-6 sodium ethanolate 
• 1914-21-2 N-ethoxyphthalimide 
• 18498-61-8 N-ethoxy-acetimidic acid ethyl ester 
• 22509-51-9 O-ethyl benzoylhydroxamic acid 
• 38483-42-0 ethyl N-ethoxycarbamate 
• 10026-13-8 phosphorus pentachloride 
• 7647-01-0 hydrogenchloride 
• 42101-48-4 acetaldehyde oxime ethyl ether 
• 80538-48-3 N-ethoxy-benzimidic acid ethyl ester 
• 10229-56-8 benz-anti-aldoxim-ethyl ether 
• 50739-69-0 ethyl p-methoxybenzohydroxamate 
• 2002-24-6 2-amino-ethanol hydrochloride 
• 75-05-8 acetonitrile 
• 52914-24-6 ethyl acetohydroxamate 

Downstream Products

• 22509-51-9 O-ethyl benzoylhydroxamic acid 
• 4747-28-8 N,O-diethylhydroxylamine 
• 90561-50-5 N'-Ethoxy-N-<4-chlor-phenyl>-harnstoff 
• 55634-12-3 2-(1-Ethoxyamino-ethylidene)-5-phenyl-cyclohexane-1,3-dione 
• 5815-55-4 N,N-Dibenzyl-O-ethyl-hydroxylamin 
• 55634-03-2 2-(1-Ethoxyamino-ethylidene)-cyclohexane-1,3-dione 
• 55634-11-2 2-[1-(ethoxyamino)ethylidene]-5,5-dimethylcyclohexane-1,3-dione 
• 104517-18-2 C₉H₁₁N₃O₄ 
• 151599-47-2 hydratropic acid N-ethoxyamide 
• 145939-00-0 2-<1-(allyloxyimino)butyl>-5,5-dimethyl-6-methoxycarbonyl-3-ethyloxyiminocyclohexan-1-one 
• 154367-11-0 N-Ethoxy-2-(4-fluorphenyl)-α-(methylaminooxy)propanamid 
• 24914-59-8 N-Ethoxy-N-2,4,6-trinitrophenylamine 

Relevant academic research and scientific papers

One-pot method for preparing O-alkyl hydroxylamine hydrochloride and N,O-dialkyl hydroxylamine hydrochloride

The invention relates to the field of organic synthesis, in particular to a one-pot method for preparing O-alkyl hydroxylamine hydrochloride and N,O-dialkyl hydroxylamine hydrochloride. The method comprises the following steps: S1, acetylation: mixing hydroxylamine hydrochloride with water and methyl acetate, and dropwise adding a sodium hydroxide solution while stirring at room temperature to obtain an intermediate acetyl hydroxylamine; S2, alkylation: dropwise adding an alkylation reagent into the reaction kettle at normal temperature, and then heating the reactants for reaction; S3, hydrolysis and purification: after the reaction is qualified, adding concentrated sulfuric acid, performing heating hydrolysis, after the reaction is qualified, adding caustic soda flakes or liquid caustic soda to adjust the pH value to 12, carrying out atmospheric distillation and hydrochloric acid acidification, cooling the product for crystallization, and centrifuging and drying the crystal to obtaina final product. According to the invention, methyl acetate is used as an acetyl protective agent, and compared with ethyl acetate, methyl acetate has the advantages of good water solubility, small reaction steric hindrance, sufficient protection, few impurities, low price and cost and the like; therefore, the method has the advantages of high product purity, simple process operation, accessible raw materials, simple wastewater components and environment friendliness, and is suitable for industrial production.

Rhodium(iii)-catalyzed directed amidation of unactivated C(sp3)-H bonds to afford 1,2-amino alcohol derivatives

A rhodium-catalyzed directed C(sp3)-H amidation to afford 1,2-amino alcohol oxime derivatives has been developed with good yields and a broad substrate scope. In previous methods for this type of reaction, 1-arylethan-1-ol oxime analogues were

High activity N - oxyl new nicotine analogs and its preparation method and application (by machine translation)

The invention belongs to the insecticide field, and in particular relates to high activity N - oxyl anabasine analogue and its preparation method and application. The invention by introducing the flexible side chain, has offered a kind of novel structure, pesticidal activity with the pyrrole insectforest quite, to the bee safely high activity N - oxyl new nicotine analogs insecticide. The insecticide solves the drug resistance of the Imidacloprid and toxic properties of the bees, can be advantageous protection of crops, horticultural plants, fruit and vegetables and the like, to prevent the emergence of the pest, increases its output, while at the same time for the activity and beneficial biological toxicity of the insecticide development explored a new path. (by machine translation)

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

A novel series of benzhydroxamate esters derived from their precursor anthranilic acids have been prepared and have been identified as potent MEK inhibitors. 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzam ide, CI-1040, was the first MEK inhibitor to demonstrate in vivo activity in preclinical animal models and subsequently became the first MEK inhibitor to enter clinical trial. CI-1040 suffered however from poor exposure due to its poor solubility and rapid clearance, and as a result, development of the compound was terminated. Optimization of the diphenylamine core and modification of the hydroxamate side chain for cell potency, solubility, and exposure with oral delivery resulted in the discovery of the clinical candidate N-(2,3-dihydroxy-propoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-b enzamide PD 0325901.

Synthesis and fungicidal activity of macrolactams and macrolactones with an oxime ether side chain

Three series of novel macrolactams and macrolactones - 12-alkoxyimino- tetradecanlactam, 12-alkoxyiminopentadecanlactam, and 12-alkoxyiminodecanlactone derivatives (7A, 7B, and 7C) - were synthesized from corresponding 12-oxomacrolactams and 12-oxomacrolactone. Their structures were confirmed by 1H NMR and elemental analysis. The Z and E isomers of 7A and 7B were separated, and their configurations were determined by 1H NMR. These compounds showed fair to excellent fungicidal activities against Rhizoctonia solani Kuehn. It is interesting that the Z and E isomers of most of the compounds have quite different fungicidal activities. The fact that the compounds have a gradual increase of fungicidal activity in the order of 7A, 7C, and 7B indicated that the macrocyclic derivatives with a hydrogen-bonding acceptor (=N-O-) and a hydrogen-bonding donor (-CONH-) on the ring, and a three methylenes distance (CH2CH2CH2) between these two functional groups, exhibited the best fungicidal activity. The bioassay also showed that 7B not only has good fungicidal activity but also may have a broad spectrum of fungicidal activities.

Synthesis and antienteroviral activity of a series of novel, oxime ether-containing pyridyl imidazolidinones

A series of pyridyl imidazolidinones were synthesized and their antiviral activity was evaluated in a plaque reduction assay. It was found that the pyridyl imidazolidinone with an ethyl oxime ether functionality, 8b, exhibited extremely high activity against human enterovirus 71.

Nodulisporic acid derivatives

The present invention relates to novel nodulosporic acid derivatives, which are acaricidal, antiparasitic, insecticidal and anthelmintic agents.

Cyclohexapeptidyl aminoalkyl ethers

There are disclosed compounds of the general formula STR1 wherein all substituents are defined herein. The compounds are useful as antibiotic and antifungal agents.

Method for the production of O-substituted hydroxylamines

A new method for the production of O-substituted hydroxylamines is disclosed. Hydroxylamine-O-sulfonic acid is reacted with alkali alkoxide in the presence of a polar aprotic solvent.