62527-77-9

Upstream product

• 14690-00-7 2-O-benzylglycerol 
• 68728-34-7 5-benzyloxy-2-phenyl-1,3-dioxane 
• 67-56-1 methanol 
• 69386-82-9 2-(benzyloxy)malonic acid 
• 108-59-8 malonic acid dimethyl ester 
• 100-51-6 benzyl alcohol 
• 31600-43-8 methyl 2-(benzyloxy)acetate 
• 79-22-1 methyl chloroformate 
• 6773-29-1 dimethyl diazomalonate 

Downstream Products

• 1264927-19-6 C₁₅H₁₈N₂O₃ 
• 1264927-23-2 C₁₅H₁₆Cl₂N₂O 
• 99984-98-2 5-(benzyloxy)pyrimidine-4,6-diol 
• 1620017-03-9 dimethyl 2-(benzyloxy)-2-(hydroxymethyl)malonate 
• 1620017-06-2 {[3-(benzyloxy)oxetan-3-yl]methoxy}(tert-butyl)diphenylsilane 
• 1620017-07-3 [3-(benzyloxy)oxetan-3-yl]methanol 
• 1620017-04-0 dimethyl 2-(benzyloxy)-2-(((tert-butyldiphenylsilyl)oxy)methyl)malonate 
• 1620017-05-1 2-(benzyloxy)-2-(((tert-butyldiphenylsilyl)oxy)methyl)propane-1,3-diol 
• 1264927-07-2 C₂₇H₂₆N₄O 
• 1264927-06-1 C₂₇H₂₃N₃O₂ 
• 1264926-93-3 N-(5-(benzyloxy)-6-p-tolylpyrimidin-4-yl)benzo[d]oxazol-6-amine 
• 1264926-88-6 4-(5-(benzyloxy)-6-p-tolylpyrimidin-4-ylamino)-2-fluorobenzonitrile 
• 1264926-86-4 5-(benzyloxy)-4-chloro-6-p-tolylpyrimidine 
• 1206181-50-1 5-(benzyloxy)-4,6-dichloropyrimidine 

Relevant academic research and scientific papers

Glycerol conversion to high-value chemicals: The implication of unnatural α-amino acid syntheses using natural resources

Glycerol derivatives are an important class of compounds, which have great applications as basic structural building blocks in organic synthesis. O-Benzylglycerol was oxidised to produce a high-value compound in high yield using a NaOtBu-O2 system. Furthermore, the synthetic utility of the resulting product was demonstrated by its transformation into unnatural α-amino acids, thus showing the valorisation of glycerol biomass.

NON-FUSED TRICYCLIC COMPOUNDS

Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

A new and versatile synthesis of 3-substituted oxetan-3-yl methyl alcohols

We have developed a novel route for the efficient synthesis of pharmaceutically significant 3-substituted oxetan-3-yl methyl alcohols starting from readily available malonates. The synthesis harnesses the diversity of malonate chemistry and allows access to a range of oxetanes, which exemplifies the versatility of this procedure.

A new and versatile synthesis of 3-substituted oxetan-3-yl methyl alcohols

We have developed a novel route for the efficient synthesis of pharmaceutically significant 3-substituted oxetan-3-yl methyl alcohols starting from readily available malonates. The synthesis harnesses the diversity of malonate chemistry and allows access to a range of oxetanes, which exemplifies the versatility of this procedure.

Asymmetric synthesis of (R)-(-)-chlozolinate through a chemoenzymatic procedure

A new asymmetric synthesis of (R)-chlozolinate 1, an important antifungal agent, based on the enzymatic asymmetrization of diethyl 2-benzyloxy-2-methylmalonate, is reported.