62530-49-8Relevant academic research and scientific papers
The synthesis of (Z)-4-oxo-4-(arylamino)but-2-enoic acids derivatives and determination of their inhibition properties against human carbonic anhydrase I and II isoenzymes
Oktay, Koray,K?se, Leyla Polat,?endil, K?v?lc?m,Gültekin, Mehmet Serdar,Gül?in, ?lhami,Supuran, Claudiu T.
, p. 939 - 945 (2016/10/09)
The synthesis of (Z)-4-oxo-4-(arylamino)but-2-enoic acid (4) derivatives containing structural characteristics that can be used for the synthesis of several active molecules, is presented. Some of the butenoic acid derivatives (4a, 4c, 4e, 4i, 4j, 4k) are
A novel approach to isoindolo[2,1-a]indol-6-ones
Duncanson, Philip,Cheong, Yuen-Ki,Motevalli, Majid,Griffiths, D. Vaughan
supporting information; experimental part, p. 4266 - 4279 (2012/07/13)
A convenient route to isoindolo[2,1-a]indol-6-ones has been developed starting from the appropriate 2-(N-phthaloyl)benzoic acids. Formation of the acid chlorides with thionyl chloride followed by heating with triethyl phosphite in a suitable solvent resulted in a multistep reaction giving tetracyclic β-ketophosphonates that on reduction with sodium borohydride gave the required indolones in good overall yields. Analogous β-ketophosphonates were also prepared starting with N,N-(1,8-naphthaloyl)-2-aminobenzoic acid and 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acids although of these only the naphthaloyl product could be reduced with sodium borohydride without cleaving the amide bond in the ring system.
1H and 13C NMR spectra for a series of arylmaleamic acids, arylmaleimides, arylsuccinamic acids and arylsuccinimides
Trujillo-Ferrara, Jose,Santillan, Rosa,Beltran, Hiram I.,Farfan, Norberto,Hoepfl, Herbert
, p. 682 - 686 (2007/10/03)
The 1H and 13C NMR spectra of 17 succinic anhydride derivatives and 25 maleic anhydride derivatives were completely assigned using one- and two-dimensional NMR techniques. Copyright
REACTIONS OF CYCLIC ANHYDRIDES XVI. A NOVEL APPROACH TO ANGULAR OXYGENATED PYRROLOBENZOXAZINONES
Balasubramaniyan, V.,Argade, N. P.
, p. 835 - 842 (2007/10/02)
o-Carboxymaleanilic acids IIIa-g when treated with sodium acetate-acetic anhydride underwent double cyclisation leading to pyrrolobenzoxazinones Va-g carrying an angular acetate.A one-flask reaction of dimethylmaleic anhydride and phthalic anhydride with anthranilic acid furnished the angular hydroxy benzoxazinones IVh and IVi respectively, which were converted to the corresponding acetates Vh and Vi.The acetates Va, Vc, Vf, Vg and Vi underwent solvolysis to the corresponding methyl ethers (VII) on refluxing with anhydrous methanol.
Ortho Substituent Effects in Amide Hydrolysis of Maleanilic Acid Derivatives. Stabilization of Positive Charge Developed in the Transition State
Suh, Junghun,Kim, Mahn Joo,Kim, Chong Bok
, p. 2453 - 2456 (2007/10/02)
The effects of ortho substituents on the rate of the hydrolysis of maleanilic acid derivatives have been studied.The rate is enhanced up to 55 times by polar substituents, while it is retarded greatly by nonpolar substituents.The acceleration by the polar
Preparation and Characterization of Hetero-bifunctional Cross-linking Reagents for Protein Modifications
Kitagawa, Tsunehiro,Shimozono, Takuro,Aikawa, Tadaomi,Yoshida, Toyokichi,Nishimura, Haruki
, p. 1130 - 1135 (2007/10/02)
Ten aromatic and aliphatic cross-linking reagents of hetero-bifunctional type were synthesized as part of a search for useful reagents of this type.All of the reagents possess two selectively reactive groups a maleimide group which can combine with a thiol group via its double bond and an N-Hydroxysuccinimidyl ester (one of the most hydrophilic active esters), which can react with an ammmine group.It was found that the active esters of the reagents tested were mostly more reactive with lysine than with leucine, and acylated amino acids more rapidly at pH 8.0 than at pH 7.0.It was also found that the stability of the maleimide group in the compounds tested depends largely upon the pH of the buffer used.The most stable pH was 5.0-6.0.To use one of the present compounds as a cross-linker, the crystalline reagent should be dissolved in tetrahydrofuran of dioxane and the solution used for cross-linking.The acylation step should be carried out first with thiol addition to the maleimide group as the second step.The optimum pH of the buffer used for the first step is slightly basic.The reaction time should be limited to less than 1 hr.When the first step is over, the pH of the reaction mixture should be changed to 5.0-6.0.Keywords---cross-linker; hetero-bifunctional reagent; reactivity of N-hydroxy-succinimidyl ester; stability of maleimide residue; N-(maleimidobenzoyloxy)succinimide derivative; N-(maleimidoalkyloxy)succinimide derivative
2'-Carboxy Maleianilic Acid as Analytical Reagent for the Determination and Separation of Zr(IV) and Th(IV)
Singh, Nepal,Gupta, C. S.
, p. 357 - 359 (2007/10/02)
2'-carboxy maleianilic acid has been found to be a selective reagent for the estimation of zirconium and thorium and their separation from a binary mixture.The acid gives white crystalline precipitate at pH 4.5 - 7.0 of a composition 2 and 2 at 130-140degC.The ions Mg(II), Co(II), Zn(II), Cd(II), Ni(II), Hg(II), Cu(II), Ca(II), Sr(II), Pr(III), Bi(III), Sm(III), La(III), Cr(III), CH2COO(1-), Cl(1-), Br(1-), NO3(1-), CNS(1-), S2O3(2-), SO4(2-) and BO3(3-) do not interfere in the determination of zirconium and thorium.
