62558-60-5Relevant academic research and scientific papers
New efficient synthesis of 1,4-benzodiazepin-5-ones by catalytic aza-Wittig reaction
Wang, Long,Qin, Ru-Qing,Yan, Hong-Ye,Ding, Ming-Wu
, p. 3522 - 3528 (2015/11/17)
1,4-Benzodiazepin-5-ones were synthesized in 71-89% yields from 2-isocyanato-N-(2-oxoalkyl)benzamides via a new catalytic intramolecular aza-Wittig reaction. Starting from easily accessible phthalic anhydride and α-arylamino ketones, the corresponding 2-{[(2-oxoalkyl)amino]carbonyl}benzoic acids underwent sequential formation of the acid azide and Curtis rearrangement to give 2-isocyanato-N-(2-oxoalkyl)benzamides that were reacted directly to give the final 2,4-diaryl-3,4-dihydro-5H-1,4-benzodiazepin-5-ones and 4-aryl-2-tert-butyl-3,4-dihydro-5H-1,4-benzodiazepin-5-ones.
Iridium-catalyzed X-H insertions of sulfoxonium ylides
Mangion, Ian K.,Nwamba, Ikenna K.,Shevlin, Michael,Huffman, Mark A.
supporting information; experimental part, p. 3566 - 3569 (2011/02/22)
Image Persented The unique reactivity of sulfoxonium ylides as a carbene source is described for a variety of X-H bond insertions, taking advantage of a simple, commercially available iridium catalyst. This method has applications in both intra- and intermolecular reactivity, including a practical ring-expansion strategy for lactams. The safety and stability of sulfoxonium ylides recommend them as preferable surrogates to traditional diazo ketones and esters.
PREPARATION OF NEW THIOHYDROXAMIC ACID DERIVATIVES: SYNTHESIS OF SUBSTITUTED 1-HYDROXY-1,2-DIHYDROIMIDAZOLE-2-THIONES
Barton, Derek H. R.,Chern, Ching-Yu,Tachdjian, Catherine
, p. 793 - 806 (2007/10/02)
A general method for the synthesis of the title compounds is reported.The N-phenacylarylamines (11), prepared from the corresponding phenacyl bromides (9) and arylamines (10), give the thiono (or dithio) carbamates (12) on treatment with phenoxythionocarb
A convenient synthesis of α-anilinoacetophenones using hypervalent iodine
Prakash, Om,Rani, Neena,Goyal, Seema
, p. 349 - 350 (2007/10/02)
Hypervalent iodine oxidation of acetophenones (1) with benzene, followed by treatment with appropriate aniline, provides a new, convenient and useful route to the synthesis of α-anilinoacetophenones (3a-h).
