62559-37-9

Usage

Uses

Used in Food and Beverage Industry:
4-Hydroxy-3-phenylbutan-2-one is used as a flavoring agent for its characteristic aroma and taste, enhancing the flavor profiles of various food and beverage products.
Used in Cosmetics and Perfumery:
Raspberry ketone is utilized as a fragrance ingredient in cosmetics and perfumes, adding a pleasant scent to these products.
Used in Weight Loss Supplements:
4-Hydroxy-3-phenylbutan-2-one is used as a weight loss supplement due to its potential to increase metabolism and fat breakdown, although more research is needed to confirm its effectiveness and safety in humans.
Used in Anti-Inflammatory Applications:
Raspberry ketone is being studied for its potential anti-inflammatory properties, which could be beneficial in managing inflammation-related conditions. However, further research is necessary to fully understand its impact and appropriate usage.

Upstream product

• 110-88-3 1,3,5-Trioxan 
• 43108-63-0 1-phenyl-2-trimethylsiloxy-1-propene 
• 101017-92-9 syn-/anti-1,2-Epoxy-3-phenylbutan-3-ol 
• 96-09-3 styrene oxide 
• 75-05-8 acetonitrile 
• 63726-68-1 3-Oxo-2-phenylbutanal 

Downstream Products

• 57502-36-0 3-methyl-2-phenylbut-3-en-1-ol 

Relevant academic research and scientific papers

Metal-free, one-pot, sequential protocol for transforming ,-epoxy ketones to -hydroxy ketones and -methylene ketones

A new sequential, one-pot protocol for transforming 1,3-disubstituted 2,3-epoxy ketones to β;-hydroxy ketones and α-methylene ketones has been developed. Reaction of epoxy ketones with boron trifluoride etherate (BF3·OEt2) generates the cationic intermediates by regioselective epoxide ring opening and an acyl shift. Then, a treatment of these cations with 2-aryl-1,3-dimethylbenzimidazolines (DMBIH) results in formation of 1,2-disubstituted 3-hydroxy ketones. DMBIH serves as a hydride donor in the second step of this process. Finally, the β;-hydroxy ketones can be converted to 1,2-disubstituted 2-methylene ketones by treatment with methanesulfonic acid or a combination of methanesulfonyl chloride and triethylamine. Importantly, the sequential steps involved in formation of the α-methylene ketone products can be carried out in one pot.

Titanocene-promoted intermolecular couplings of epoxides with nitriles. An easy access to β-hydroxyketones

(Chemical Equation Presented) Radical couplings of epoxides and nitriles mediated by Cp2TiCl provide a diastereoselective route to the synthesis of β-hydroxyketones. The conditions of this "aldol- like" reaction are mild enough to avoid the dehydration of the β-hydroxyketone. The scope of the coupling reaction with functionalized and tetrasubstituted epoxides has been studied. The radical character of the coupling reactions is demonstrated.

Stereoselective Construction of Quaternary Centres at Ambient Temperature by the Highly Stereocontrolled Migration of Groups Containing sp-, sp2-, and sp3-Hybridized Carbon Atoms

A very highly diastereoselective semipinacol rearrangement of 2,3-epoxy alcohols mediated by tin(IV) chloride at ambient temperatures is shown to be applicable to a wide variety of migration groups including methyl, tert-butyl, cyclopropyl, vinyl, alkynyl