62596-45-6

Upstream product

• 141-97-9 ethyl acetoacetate 
• 100-66-3 methoxybenzene 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 768-60-5 4-methoxyphenylacetylen 
• 1608-24-8 3-(2,2-difluoroethenyl)anisole 
• 32117-52-5 1-(1-(4-methoxyphenyl)ethylidene)-2-tosylhydrazine 
• 2009-97-4 ethyl 2-diazo-3-oxobutanoate 
• 64-17-5 ethanol 
• 83490-93-1 ethyl 1-(3-methoxyphenyl)-1,4-pentandione-3-carboxylate 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 55991-65-6 [1-(4-methoxyphenyl)vinyloxy]trimethylsilane 
• 2196-99-8 2-chloro-1-(4-methoxyphenyl)ethanone 

Downstream Products

• 111787-87-2 2-methyl-5-(4-methoxyphenyl)furan-3-carboxylic acid 
• 111787-92-9 [5-(4-methoxyphenyl)-2-methylfuran-3-yl]methanol 
• 18476-67-0 2-(4-methoxyphenyl)-5-methylbenzofuran 

Relevant academic research and scientific papers

By accompanies two fluorine olefin preparing multi-substituted furan derivatives

The invention relates to a method for preparation of a polysubstituted furan derivative, the method comprises the following main steps: in the presence of a copper salt and an oxyacid salt of an IA element in the element periodic table, gem-difluoroolefin

Copper-Mediated [3 + 2] Oxidative Cyclization Reaction of N-Tosylhydrazones and β-Ketoesters: Synthesis of 2,3,5-Trisubstituted Furans

The first attempt at utilizing N-tosylhydrazones as two-carbon synthons has been successfully achieved, which underwent a copper-mediated [3 + 2] oxidative cyclization reaction to afford 2,3,5-trisubstituted furans in moderate to good yields. The features of this method include inexpensive metal catalyst, readily available substrates, high regioselectivity, and convenient operation. The studies provide important approaches for further exploration of the powerful and diverse reaction abilities of N-tosylhydrazones.

Copper-Catalyzed Coupling of 2-Siloxy-1-alkenes and Diazocarbonyl Compounds: Approach to Multisubstituted Furans, Pyrroles, and Thiophenes

We report herein copper(II)-catalyzed cyclization reactions of silyl enol ethers derived from methyl ketones with α-diazo-β-ketoesters or α-diazoketones to afford 2-siloxy-2,3-dihydrofuran derivatives or 2,3,5-trisubstituted furans, respectively, under mild conditions. The former cyclization products serve as versatile 1,4-diketone surrogates, allowing facile preparation of 2,3,5-trisubstituted furans, pyrroles, and thiophenes.

Copper-catalyzed coupling cyclization of gem -difluoroalkenes with activated methylene carbonyl compounds: Facile domino access to polysubstituted furans

A novel and efficient CuI-catalyzed synthesis of 2,3,5-trisubstituted furans was developed via coupling cyclization of gem-difluoroalkenes with active methylene carbonyl compounds such as 1,3-dicarbonyl compounds, acetoacetonitrile, and phenylsulfonylacet

Cu(I)-catalyzed reaction of diazo compounds with terminal alkynes: A direct synthesis of trisubstituted furans

A method for the synthesis of tri-substituted furans has been developed based on Cu(I)-catalyzed reaction of terminal alkynes with β-keto α-diazoesters. This method for the synthesis of 2,3,5-trisubstituted furans is operationally simple and applicable to

Silver-mediated oxidative C-H/C-H functionalization: A strategy to construct polysubstituted furans

A novel silver-mediated highly selective oxidative C-H/C-H functionalization of 1,3-dicarbonyl compounds with terminal alkynes for the creation of polysubstituted furans and pyrroles in one step has been demonstrated. Promoted by the crucial silver specie

One-pot synthesis of furans using base- and acid-supported reagents Na 2CO3/Al2O3-PPA/SiO2'

A convenient method for the one-pot synthesis of furans from -keto esters and -halo ketones was developed using an acid- and base-supported reagent system Na2CO3/Al2O3-PPA/SiO2'. The condensation reaction of triketones, which are formed from the reaction of -keto esters with -halo ketones in the presence of Na2CO 3/Al2O3, was promoted by PPA/SiO2 to give the corresponding furans in good yields. This method is simple and easy to perform in comparison with stepwise processes, and the yields are good.

DIRECT SYNTHESIS OF FURANS BY 3 + 2 CYCLOADDITIONS BETWEEN RHODIUM(II) ACETATE STABILIZED CARBENOIDS AND ACETYLENES

When appropriate substituents are used, rhodium(II) acetate catalyzed decomposition of diazocarbonyls in the presence of acetylenes results in the formation of furans, derived from dipolar intermediates.