62613-57-4

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 529-27-1 2-methylphenylhydrazine 
• 95-53-4 o-toluidine 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 696-62-8 para-iodoanisole 
• 119072-54-7 2,6-dimethylphenyl isonitrile 
• 607-92-1 2,6-dimethylformanilide 
• 87-62-7 2,6-dimethylaniline 
• 2475-92-5 4-methoxyacetophenone oxime 
• 615-37-2 ortho-methylphenyl iodide 
• 96155-57-6 (E)-1-(4-methoxyphenyl)ethanone O-acetyl oxime 
• 96155-57-6 1-(4-methoxyphenyl)ethanone O-acetyl oxime 

Downstream Products

• 1017260-06-8 C₂₆H₂₉BrN₂O₃Si 

Relevant academic research and scientific papers

Polysubstituted Indole Synthesis via Palladium/Norbornene Cooperative Catalysis of Oxime Esters

Polysubstituted indoles are prevalent in pharmaceuticals, agrochemicals, and organic materials. Presented herein is the fact that polyfunctionalized indoles can be efficiently constructed from easily accessible oxime esters and aryl iodides, involving a palladium/norbornene synergistic synthesis. The reaction is enabled by a unique class of electrophiles in palladium/norbornene cooperative catalysis, which are oxime esters derived from simple ketone. The broad substrate scope and high functional group tolerance could make this method attractive for the synthesis of polysubstituted indoles.

Method for synthesizing 2-substituted indole compound from iodobenzene and oxime ester under catalysis of palladium

The invention belongs to the technical field of organic chemistry, and discloses a method for synthesizing a 2-substituted indole compound from iodobenzene and oxime ester under the catalysis of palladium. The method comprises the following steps of reacting an oxime ester compound with iodobenzene under the action of a palladium catalyst, a phosphine ligand and norbornene by taking an organic solvent as a reaction medium in a protective atmosphere, and carrying out subsequent treatment to obtain the 2-substituted indole compound. According to the method, palladium is used as a catalyst, the phosphine ligand is adopted, the yield is high, and the substrate applicability is wide. In addition, the oxime ester compound is used as a raw material, and the method has the advantages of cheap and easily-prepared raw materials, simple operation, mild reaction conditions and the like.

Palladium-catalyzed cascade process consisting of isocyanide insertion and benzylic C(sp3)-H activation: Concise synthesis of indole derivatives

Synthesis of the indole skeleton was achieved using a Pd-catalyzed cascade process consisting of isocyanide insertion and benzylic C(sp3)-H activation. It was found that slow addition of isocyanide is effective for reducing the amount of catalyst needed and Ad2PnBu is a good ligand for C(sp3)-H activation. The construction of the tetracyclic carbazole skeleton was also achieved by a Pd-catalyzed domino reaction incorporating alkyne insertion.

Antibacterial activity of a novel series of 3-bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives - An extended structure-activity relationship study

Compounds containing 3-bromo-2,5-dihydro-1H-2,5-pyrroledione and indole substructures were found to have antibacterial activity against resistant strains of Staphylococcus aureus and some other Gram positive bacteria. The investigated compounds exhibit mi

2-Phenyl-indole derivatives

The present invention relates to new stabilizers of polymers and co-polymers of vinyl chloride corresponding to the general formula: STR1 wherein R1, R2, R3, R4, R5 and R6, which are the sa