62616-14-2Relevant academic research and scientific papers
N-HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT FOR THE TREATMENT OF PARASITIC DISEASES
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Page/Page column 95, (2012/04/17)
This invention relates to certain N-heteroaryl compounds that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to the preparation of the N-heteroaryl compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.
Novel Annelation Method to Pyridine and Isoquinoline by Photochemical Means
Kaneko, Chikara,Uchiyama, Keiji,Sato, Masayuki,Katagiri, Nobuya
, p. 3658 - 3671 (2007/10/02)
Intramolecular photoaddition reactions of 2-(ω-alkenyl)isoquinolin-1(2H)-ones and 1-(ω-alkenyl)pyridin-2(1H)-ones were examined, and the regioselectivity and dependence of these reactions on the length of methylene chain in the alkenyl group were clarified.By utilizing these reactions, a synthetic route to indolizine and quinolizine derivates was elaborated.By an extension of this approach to the intermolecular reaction, 6-methoxy-3-methyl-1,2-dihydrocyclobutapyridin-4(3H)-one was synthesized from 4,6-dimethoxy-1-methylpyridin-2(1H)-one.Keywords-2+2 photocycloaddition; intramolecular photoaddition; photocycloreversion; annelation; indolizine; quinolizine; cyclobutapyridine; 4,6-dimethoxypyridin-2(1H)-one; 1-(ω-alkenyl)pyridin-2(1H)-one; 2-(ω-alkenyl)isoquinolin-1(2H)-one
