6262-22-2

Basic information

• Product Name: N-(4-formamidophenyl)formamide
• Synonyms: N-(4-formamidophenyl)formamide;N,N'-(1,4-Phenylene)diformamide
• CAS NO: 6262-22-2
• Molecular Formula: C₈H₈N₂O₂
• Molecular Weight: 164.16132
• Mol File: 6262-22-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 211 °C
• Appearance: /
• CAS DataBase Reference: N-(4-formamidophenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-formamidophenyl)formamide(6262-22-2)
• EPA Substance Registry System: N-(4-formamidophenyl)formamide(6262-22-2)

Safety Data

• Hazardous Substances Data: 6262-22-2(Hazardous Substances Data)

Usage

General Description

N-(4-formamidophenyl)formamide is a chemical compound with the molecular formula C8H8N2O2. It is an amide derivative of formanilide, and is also known as N'-formylformanilide. N-(4-formamidophenyl)formamide is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is a white to light yellow solid that is sparingly soluble in water but soluble in most organic solvents. N-(4-formamidophenyl)formamide is primarily used in laboratory research and chemical synthesis, and is not widely used in industrial applications. It is important to handle this chemical with care and according to proper safety procedures due to its potential health hazards.

Upstream product

• 100-25-4 para-dinitrobenzene 
• 64-18-6 formic acid 
• 108-24-7 acetic anhydride 
• 106-50-3 1,4-phenylenediamine 
• 1988-22-3 4-chlorophenyl formate 
• 100-01-6 4-nitro-aniline 
• 77287-34-4 formamide 
• 64-19-7 acetic acid 
• 109-94-4 formic acid ethyl ester 
• 144-62-7 oxalic acid 

Downstream Products

• 98963-72-5 C₂₀H₄Cl₁₂N₂S₂ 
• 10509-50-9 N,N'-Bis-<2,2-diphenyl-vinyl>-p-phenylendiamin 
• 6632-40-2 N,N'-Dimethyl-N,N'-diformyl-p-phenylenediamine 
• 1620164-64-8 octaethyl benzene-1,4-bis[aminomethylidene(bisphosphonate)] 
• 851916-02-4 benzene-1,4-bis[aminomethylidene(bisphosphonic)] acid 
• 17788-94-2 4,4''-dibromo-p-terphenyl 
• 1762-84-1 4-bromo-p-terphenyl 
• 92-94-4 [1,1';4',1'']terphenyl 
• 105-10-2 N,N'-dimethyl-p-phenylenediamine 
• 935-16-0 1,4-phenylenediisocyanide 
• 2666-71-9 1,4-phenylene diimidophosgene 
• 857579-30-7 N,N'-dinitroso-N,N'-p-phenylene-bis-formamide 

Relevant articles and documents

En route to molecular bracelets: The synthesis of linear pentacyclic bis(benzodiazocino)benzenes

The title compounds, namely dibenzo[b,b']benzo[1,2-f:4,5- f']bis[1,5]diazocines, have been synthesized in a single step in two alternative ways by application of the 'tertiary amino effect': (i) the action of bis-Vilsmeier reagents derived from N,N'-dimethyl-N,N'-diformyl-p- phenylenediamine upon 4-substituted N,N-dimethylanilines, and (ii) the action of Vilsmeier reagents derived form 4-substituted N-methylformanilides on bis(dimethylamino)benzenes.

Catalyst-Free Transamidation of Aromatic Amines with Formamide Derivatives and Tertiary Amides with Aliphatic Amines

A simple catalyst- and promoter-free protocol has been developed for the transamidation of weakly nucleophilic aromatic amines with formamide derivatives and low-reactivity tertiary amides with aliphatic amines. This strategy is advantageous because no catalyst or promoters are needed, no additives are required, separation and purification is easy, and the reaction is scalable. Significantly, this strategy was further applied to synthesize several pharmaceutical molecules on a gram scale, and excellent yields were achieved.

Supported Palladium Nanoparticles Catalyzed Reductive Carbonylation of Nitroarenes to N-Arylformamides

A facile reductive carbonylation reaction of nitroarenes to N-arylformamide synthesis was investigated under polymer supported palladium (Pd@PS) nanoparticles catalyzed conditions. Dual role of oxalic acid dihydrate ((CO2H)2 ? 2H2O) as H2 source for hydrogenation and CO source for carbonylation reaction for desired products synthesis was critically investigated under favorable DMF solvent conditions. Several cross experiments were performed to establish the best possible hypothesis for the proposed mechanism and understanding about the involvement of CO in the reaction pathway. Further, ortho-substituted nitroarenes were found to be highly specific for facile para-hydroxylation to give corresponding para-hydroxy N-aryl formamides. (Figure presented.).