62625-55-2

Upstream product

• 38204-31-8 2-((4-methoxyphenylcarbonothioyl)thio)acetic acid 
• 58547-63-0 4-Methoxy-S-carboxymethyl-thiobenzoesaeure-piperidinium 
• 42285-17-6 (4-methoxyphenyl)(piperidin-1-yl)methanethione 
• 121-98-2 methyl 4-methoxybenzoate 
• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 14537-65-6 isopropyl-[5-(4-methoxy-phenyl)-[1,3,4]thiadiazol-2-yl]-amine 
• 107402-76-6 2-(4-methoxyphenyl)-8-methyl-1-thia-3,4,8-triazaspiro(4.5)dec-2-ene 
• 107402-74-4 bis-(5-(4-methoxyphenyl)-2,3-dihydro-1,3,4-thiadiazol-3-yl)methane 
• 113369-20-3 2-(2-acetylaminobenzoyl)-5-p-methoxyphenyl-1,3,4-thiadiazole 
• 113369-25-8 C₁₈H₁₅N₃O₃S 
• 78344-56-6 9-acetyl-9a-hydroxy-2-p-methoxyphenyl<1.3.4>thiadiazino<6.5-b>indole 
• 113369-22-5 N-{2-[N'-(4-Methoxy-thiobenzoyl)-hydrazinooxalyl]-phenyl}-acetamide 
• 17453-03-1 2,5-Bis-<4-methoxy-phenyl>-1,3,4-thiadiazol 
• 1456-67-3 2-(4'-methoxyphenyl)-5-phenyl-1,3,4-thiadiazole 
• 15311-20-3 2-(4-methoxyphenyl)-5-(pyridin-3-yl)-1,3,4-thiadiazole 
• 82243-14-9 2-(4-methoxyphenyl)-1-thia-3,4-diazaspiro(4.5)dec-2-ene 
• 107402-79-9 4-[5-(4-Methoxy-phenyl)-2-methyl-2,3-dihydro-[1,3,4]thiadiazol-2-yl]-butyric acid 
• 82243-11-6 5-(4-methoxyphenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazole 
• 107402-73-3 2-(4-chlorophenyl)-5-(4-methoxyphenyl)-2,3-dihydro-1,3,4-thiadiazole 

Relevant academic research and scientific papers

2,5-Disubstituted thiadiazoles as potent β-glucuronidase inhibitors; Synthesis, in vitro and in silico studies

Twenty-five thiadiazole derivatives 1–25 were synthesized from methyl 4-methoxybenzoate via hydrazide and thio-hydrazide intermediates, and evaluated for their potential against β-glucuronidase enzyme. Most of the compounds including 1 (IC50 = 26.05 ± 0.60 μM), 2 (IC50 = 42.53 ± 0.80 μM), 4 (IC50 = 38.74 ± 0.70 μM), 5 (IC50 = 9.30 ± 0.29 μM), 6 (IC50 = 6.74 ± 0.26 μM), 7 (IC50 = 18.40 ± 0.66 μM), and 15 (IC50 = 18.10 ± 0.53 μM) exhibited superior activity potential than the standard D-saccharic acid-1,4-lactone (IC50 = 48.4 ± 1.25 μM). Molecular docking studies were conducted to correlate the in vitro results and to identify possible mode of interaction with enzyme active site.

5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2)

5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2) have been prepared via commercially available starting materials. Selected compounds 23, 33-35 show sub-micromolar ADAMTS-5 potency and strong SAR trends with selectivity over the related metalloproteases ADAMTS-4 (Aggrecanase-1), MMP12, and MMP13. This series of compounds represents progress toward a selective ADAMTS-5 inhibitor as a disease modifying osteoarthritis drug.

HETEROCYCLIZATION OF DERIVATIVES OF THIONCARBOXYLIC ACIDS TO 1,3,4-THIADIAZOLES UNDER THE ACTION OF TERT-BUTYL HYPOCHLORITE

A method for synthesis of 2-alkyl-5-aryl- and 2,5-diaryl-1,3,4-thiadiazoles by successive reaction of thioamides with tert-butyl hypochlorite and benzothiohydrazides was developed.The first step in the formation of 1,3,4-thiadiazoles consists of oxidation

SEMICARBAZONES AND THIOSEMICARBAZONES OF THE HETEROCYCLIC SERIES. XLIV. CYCLIZATION OF ISATIN AND 1-ACETYLISATIN 3-THIOBENZOYLHYDRAZONES

Isatin 3-thiobenzoylhydrazone undergoes cyclization with the addition of the sulfur atom to the C3 atom and closure of the thiadiazole ring.In contrast, 3-thioaroylhydrazones of 1-acetylisatin undergo cyclization with participation of C2 and close the thiadiazine ring with the formation of derivatives of the new heterocyclic system thiadiazinoindole.