1456-67-3Relevant academic research and scientific papers
Structural studies of 2,5-disubstituted 1,3,4-thiadiazole derivatives from dithioesters under the mild condition: Studies on antioxidant, antimicrobial activities, and molecular docking
Gowda, Kemparaje,Kanchugarkoppal, Rangappa S.,Kempegowda, Mantelingu,Nagarakere, Sandhya C.,Rangappa, Shobith,Swarup, Hassan A.
, (2020/04/27)
A series of 2,5-disubstituted 1,3,4-thiadiazole was synthesized and evaluated for their antioxidant and molecular docking studies. These molecules were efficiently synthesized under mild and inexpensive starting material. Construction of these molecules developed using substituted aldehydes and substituted dithioesters in presence of NCS (N-Chorosuccinimide). The compounds 4a, 4b, 4c, 4f, and 4k showed good antibacterial and antioxidant activity among which, 4k possess excellent antibacterial and antioxidant activity. The results of antioxidant activity studies revealed that compound 4k manifested profound antioxidant potential. The molecular docking study was performed with respective newly synthesized compounds to ascertain the binding mode of 4k with respect to the critical proteins involved in biosynthesis and metabolic pathways.
An efficient one-pot synthesis of 2,5-disubstituted-1,3,4-thiadiazoles from aldehydes and hydrazides using Lawesson’s reagent
Ko, Inseok,Park, Soojin,Lee, Goeun,Kim, Hakwon
, p. 67 - 78 (2019/03/07)
Five-membered heterocyclic-ring systems, such as thiadiazoles, remain an important and prevalent scaffold in the development of novel leads in medicinal chemistry for a variety of therapeutic targets. A two-step, one-pot synthesis of 2,5-disubstituted-1,3,4-thiadiazole derivatives from aryl hydrazides and aryl aldehydes using Lawesson’s reagent is described, yielding 2,5-disubstituted-1,3,4-thiadiazoles in moderate-to-high yields. Based on preliminary biological experiments, some of the newly synthesized thiadiazoles show antioxidant activity.
Preparation method and application of multifunctional ultraviolet absorbent
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, (2017/04/28)
The invention relates to a preparation method and application of a multifunctional ultraviolet absorbent for terylene. The general structural formula of the absorbent is as follows: formula, wherein Y is a quaternary ammonium salt group. According to the preparation method and application of the multifunctional ultraviolet absorbent for terylene disclosed by the invention, the dyeing mode of the ultraviolet absorbent to terylene is similar to disperse dyes, and fabrics can be subjected to anti-ultraviolet finishing by using a high-temperature and high-pressure exhausting method and can also be dyed with the disperse dyes in the same bath; the finished fabrics not only have good anti-ultraviolet properties, but also have the effects of killing or inhibiting Gram-positive bacteria and Gram-negative bacteria represented by staphylococcus aureus and Escherichia coli; and meanwhile, the fabrics have good anti-static function.
Eosin Y catalyzed visible-light-promoted one - Pot facile synthesis of 1,3,4- thiadiazole
Srivastava, Vishal,Singh, Pravin K.,Singh, Praveen P.
, p. 59 - 65 (2015/05/27)
A novel one-pot visible light irradiated synthesis of 1,3,4-thiadiazole from aldehydes and thioacyl hydrazides have been reported in presence of eosin Y as an organophotoredox catalyst at room temperature under aerobic condition. This synthesis includes a
C-H arylation of azaheterocycles: A direct ligand-free and Cu-catalyzed approach using diaryliodonium salts
Kumar, Dalip,Pilania, Meenakshi,Arun,Pooniya, Savita
supporting information, p. 6340 - 6344 (2014/08/18)
An efficient and high yielding Cu-catalyzed direct C-H arylation of azaheterocycles including oxadiazoles, thiadiazoles, benzoxazoles and benzothiazoles has been achieved by employing easily accessible diaryliodonium salts. the Partner Organisations 2014.
Pd/Cu-catalyzed C-H arylation of 1,3,4-thiadiazoles with (hetero)aryl iodides, bromides, and triflates
Vachhani, Dipak D.,Sharma, Abhishek,Van Der Eycken, Erik
, p. 8768 - 8774 (2012/11/07)
The direct C-H arylation of 1,3,4-thiadiazoles with a wide range of (hetero)aryl iodides, bromides, and triflates is described using a Pd/Cu-catalyzed protocol. The methodology is compatible with substrates possessing electron-donating or electron-withdrawing substituents and also tolerates sterically hindered aryl halides. The utility of the developed protocol is demonstrated by a one-pot C-H arylation-Suzuki coupling sequence.
The synthesis, electrochemical and fluorescent properties of monomers and polymers containing 2,5-diphenyl-1,3,4-thiadiazole
Tao, Yongxin,Xu, Qingfeng,Lu, Jianmei,Yang, Xuebo
scheme or table, p. 153 - 158 (2010/11/03)
Three, 2,5-diphenyl-1,3,4-thiadiazole-containing vinyl monomers and their polymers were synthesized and the HOMO and LUMO energies of the compounds, as estimated from cyclic voltammetry data, were -6.35 to -6.14 eV and -3.02 to -2.84 eV, respectively. The optical band gaps (Eg) were similar to those determined from cyclic voltammograms. The fluorescent emission spectra of all monomers and polymers displayed either blue or green light emission.
Greener and rapid access to bio-active heterocycles: one-pot solvent-free synthesis of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles
Polshettiwar, Vivek,Varma, Rajender S.
, p. 879 - 883 (2008/09/17)
A novel one-pot solvent-free synthesis of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles by condensation of acid hydrazide and triethyl orthoalkanates under microwave irradiations is reported. This green protocol was catalyzed efficiently by solid supported NafionNR50 and phosphorus pentasulfide in alumina (P4S10/Al2O3) with excellent yields.
General facile synthesis of 2,5-diarylheteropentalenes
Vachal, Petr,Toth, Leslie M.
, p. 7157 - 7161 (2007/10/03)
Palladium-catalyzed cross-coupling reactions of various heteropentalene derivatives were systematically studied. A general three-step synthesis of 2,5-diarylheteropentalenes involving two Suzuki or Negishi couplings and a regiospecific bromination was developed. Nonsymmetrical 2,5-diaryl-furans, thiophenes, pyrroles, 1,3-thiazoles, 1,3-oxazoles, 1,3,4-thiadiazoles, and 1,3,4-oxadiazoles were prepared in 31-67% isolated yield (three steps).
