62632-15-9

Upstream product

• 79-37-8 oxalyl dichloride 
• 4001-73-4 2-Bromobenzamide 
• 7154-66-7 2-bromobenzoic acid chloride 
• 88-65-3 2-bromobenzoic-acid 

Downstream Products

• 64628-07-5 1-(2-Bromo-benzoyl)-3-[3-chloro-4-(2-chloro-1,1,2-trifluoro-ethoxy)-phenyl]-urea 
• 83173-29-9 1-(2-Bromo-benzoyl)-3-[3-chloro-4-(5-iodo-pyrimidin-2-yloxy)-phenyl]-urea 
• 1123689-65-5 C₁₈H₁₃BrN₄O₂S 
• 88523-63-1 1-(2-BROMOBENZOYL)-3-(6-METHYL-5-PHENYL-2-PYRIDYL)UREA 
• 69816-60-0 1-(2-bromo-benzoyl)-3-[5-(4-bromo-phenyl)-6-methyl-pyrazin-2-yl]-urea 
• 64628-37-1 1-(2-Bromo-benzoyl)-3-(3-trifluoromethoxy-phenyl)-urea 
• 64627-95-8 1-(2-Bromo-benzoyl)-3-(3-trifluoromethylsulfanyl-phenyl)-urea 
• 64628-29-1 1-(2-Bromo-benzoyl)-3-(3-chloro-4-trifluoromethylsulfanyl-phenyl)-urea 
• 64628-21-3 1-(2-Bromo-benzoyl)-3-(3-chloro-4-trifluoromethoxy-phenyl)-urea 
• 64628-05-3 1-(2-Bromo-benzoyl)-3-(4-trifluoromethylsulfanyl-phenyl)-urea 
• 64628-47-3 1-(2-Bromo-benzoyl)-3-(4-trifluoromethoxy-phenyl)-urea 

Relevant academic research and scientific papers

Scalable Synthetic Strategy for Unsymmetrical Trisubstituted s-Triazines

A scalable synthetic strategy to produce a large variety of unsymmetrical trisubstituted 1,3,5-triazines was developed. This protocol applied in situ formed acyl isocyanate from amide to react with amidine, introducing two substituents to the 1,3,5-triazinone ring with a low production cost and a simple workup procedure. The scalability of this method was demonstrated by translating a small-scale procedure to a multi-kilogram-scale synthesis. Chlorination and a further coupling reaction with various nucleophiles could provide unsymmetrical trisubstituted 1,3,5-triazines bearing diverse functional groups.

Investigation of novel pesticides with insecticidal and antifungal activities: Design, synthesis and SAR studies of benzoylpyrimidinylurea derivatives

In order to find pesticides with insecticidal and antifungal activities, a series of novel benzoyl pyrimidinylurea derivatives were designed and synthesized. All target compounds were identified by 1H-NMR spectroscopy and HRMS. Insecticidal and antifungal activity of these compounds were evaluated and the structure-activity relationships (SAR) were clearly and comprehensively illustrated. Compound 7, with low toxicity to zebrafish (LC50 = 378.387 μg mL?1) showed 100% inhibition against mosquito (Culex pipiens pallens) at 0.25 μg mL?1. Both compounds 19 and 25 exhibited broad-spectrum fungicidal activity (>50% inhibitory activities against 13 phytopathogenic fungi), which were better than those of the commercial pesticide pyrimethanil (>50% inhibitory activities against eight phytopathogenic fungi). Furthermore, compounds 19 and 25 exhibited protective activity against Sclerotinia sclerotiorum on leaves of Brassica oleracea L. during in vivo experiments.

SINGLE MOLECULE COMPOUNDS PROVIDING MULTI-TARGET INHIBITION OF PARP AND OTHER PROTEINS AND METHODS OF USE THEREOF

The invention relates to compounds useful for inhibiting PARP and at least one other protein and to methods of treating diseases including cancer by administration of a compound(s) of Formula I-V (or pharmaceutically acceptable salts thereof) as defined herein.

Design, synthesis and fungicidal activity of N-substituted benzoyl-1,2,3,4-tetrahydroquinolyl-1-carboxamide

To find a new lead compound with high biological activity, a series of N-substituted benzoyl-1,2,3,4-tetrahydroquinolyl-1-carboxamide were designed using linking active substructures method. The target compounds were synthesized from substituted benzoic acid by four steps and their structures were confirmed by 1H NMR, IR spectrum and elemental analysis. The in vitro bioassay results indicated that some target compounds exhibited excellent fungicidal activities, and the position of the substituents played an important role in fungicidal activities. Especially, compound 5n, exhibited better fungicidal activities than the commercial fungicide flutolanil against two tested fungi Valsa Mali and Sclerotinia sclerotiorum, with EC50 values of 3.44 and 2.63 mg/L, respectively. And it also displayed good in vivo fungicidal activity against S. sclerotiorum with the EC50 value of 29.52 mg/L.

Synthesis, structure and biological activity of some new aroylurea derivatives containing 1,3,4-thiadiazole

In an extensive search for biologically active aroylurea compounds as plant growth regulators, a series of new N-aroyl-N′-[5-(E)-styryl-1,3,4- thiadiazol-2-yl]ureas have been designed and synthesized. Their structures were characterized by IR, 1H NMR, MS, elemental analysis, and single-crystal X-ray diffraction techniques. The preliminary bioassay showed that some of the title compounds exhibited good plant-growth regulating activity. Copyright Taylor & Francis Group, LLC.