62681-96-3

Usage

Uses

Used in Pharmaceutical Research:
2-(2-Fluorophenyl)-5-phenyl-1,3,4-oxadiazole is used as a drug candidate for various therapeutic purposes due to its potential antimicrobial, anti-inflammatory, and anticancer activities. Its unique chemical structure allows it to modulate biological pathways and target specific receptors, making it a promising candidate for the development of new drugs.
Used in Material Science Research:
2-(2-Fluorophenyl)-5-phenyl-1,3,4-oxadiazole is used as a building block for organic electronic materials, such as light-emitting diodes and photovoltaic devices. Its versatile properties and chemical structure make it suitable for the development of advanced materials with improved performance and functionality.
Used in Antimicrobial Applications:
In the pharmaceutical industry, 2-(2-Fluorophenyl)-5-phenyl-1,3,4-oxadiazole is used as an antimicrobial agent to target and eliminate harmful microorganisms, such as bacteria and fungi. Its unique chemical structure allows it to disrupt essential cellular processes, leading to the inhibition of microbial growth and proliferation.
Used in Anti-inflammatory Applications:
2-(2-Fluorophenyl)-5-phenyl-1,3,4-oxadiazole is used as an anti-inflammatory agent to reduce inflammation and alleviate symptoms associated with various inflammatory conditions. Its potential to modulate inflammatory pathways and target specific receptors makes it a promising candidate for the development of new anti-inflammatory drugs.
Used in Anticancer Applications:
In the field of oncology, 2-(2-Fluorophenyl)-5-phenyl-1,3,4-oxadiazole is used as an anticancer agent to target and inhibit the growth of cancer cells. Its unique chemical structure allows it to interfere with essential cellular processes, leading to the suppression of tumor growth and progression.
Used in Organic Electronic Materials:
2-(2-Fluorophenyl)-5-phenyl-1,3,4-oxadiazole is used as a building block for the development of organic electronic materials, such as light-emitting diodes and photovoltaic devices. Its versatile properties and chemical structure contribute to the creation of advanced materials with improved performance, efficiency, and functionality in electronic applications.

Upstream product

• 18039-42-4 5-Phenyl-1H-tetrazole 
• 64508-63-0 2-fluorobenzoic anhydride 
• 825-56-9 2-phenyl-1,3,4-oxadiazole 
• 348-52-7 1-Fluoro-2-iodobenzene 
• 171796-91-1 N′-[2-fluorobenzylidene]benzohydrazide 
• 613-94-5 benzoic acid hydrazide 
• 446-52-6 2-Fluorobenzaldehyde 
• 446-24-2 2-fluorobezohydrazide 
• 611-73-4 Benzoylformic acid 
• 100-47-0 benzonitrile 
• 393-52-2 2-Fluorobenzoyl chloride 

Downstream Products

• 1454693-82-3 2-(2-fluorophenyl)-5-phenyl-1,3,4-oxadiazole 

Relevant academic research and scientific papers

Electrochemical Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles from α-Keto Acids and Acylhydrazines Under Mild Conditions

1,3,4-Oxadiazoles are a kind of useful heterocycles which can be frequently found in materials and bioactive molecules. In this study, intermolecular electrochemical cyclization between α-keto acids and acylhydrazines has been developed for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles with the yield up to 91 %. This transformation can be run under mild reaction conditions in the absence of external oxidant, base and transition metal catalyst. Both symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles could be prepared according to the careful choice of the substrate combination. Gram scale synthesis also illustrates the potential application of this protocol in large preparation.

CARBAZOLE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE

A carbazole derivative is provided. The carbazole derivative is shown in formula (9):

I2-mediated oxidative C-O bond formation for the synthesis of 1,3,4-oxadiazoles from aldehydes and hydrazides

A practical and transition-metal-free oxidative cyclization of acylhydrazones into 1,3,4-oxadiazoles has been developed by employing stoichiometric molecular iodine in the presence of potassium carbonate. The conditions of this cyclization reaction also work well with crude acylhydrazone substrates obtained from the condensation of aldehydes and hydrazides. A series of symmetrical and asymmetrical 2,5-disubstituted (aryl, alkyl, and/or vinyl) 1,3,4-oxadiazoles can be conveniently generated in an efficient and scalable fashion.

Copper-mediated direct arylation of 1,3,4-oxadiazoles and 1,2,4-triazoles with aryl iodides

The copper-mediated direct arylation of 1,3,4-oxadiazoles and 1,2,4-triazoles with aryl iodides proceeds efficiently in the presence of suitable ligands and bases. This method allows the installation of a variety of aryl moieties bearing a functional group such as ketone, ester, or nitrile so as to enable the facile construction of various functionalized oxadiazole and triazole core π systems.

TETRAZOLES IN THE SYNTHESES OF 1,3,4-OXADIAZOLES

Various variants of cleavage of tetrazoles to form 1,3,4-oxadiazoles are examined.The mechanisms and synthetic potentialities of these reactions are discussed.