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Upstream product

• 1696-17-9 N,N-diethylbenzamide 
• 160693-94-7 benzophenone-(O-benzenesulfonyl oxime ) 
• 109-89-7 diethylamine 
• 7719-09-7 thionyl chloride 
• 67-66-3 chloroform 
• 93-98-1 N-phenyl benzoyl amide 
• 187347-94-0 N-[(benzotriazol-1-yl)(phenyl)methylidene]aniline 
• 4903-36-0 N-phenyl-benzimidoyl chloride 
• 98-09-9 benzenesulfonyl chloride 

Relevant academic research and scientific papers

Ph3P/I2-mediated synthesis of N,N′-disubstituted and N,N,N′-trisubstituted amidines

A convenient one-pot protocol for the synthesis of N,N′-disubstituted and N,N,N′-trisubstituted amidines is reported. In the presence of the Ph3P–I2/Et3N system, a variety of secondary amides were smoothly reacted with primary or secondary amines to afford the corresponding amidines in good to excellent yields under mild conditions.

Efficient microwave access to polysubstituted amidines from imidoylbenzotriazoles

Microwave reactions of primary and secondary amines with imidoylbenzotriazoles 6a-w gave diversely substituted amidines 7a-Aa in 76-94% yields. Convenient preparations of a variety of amides 5a-Ab (87-96%) and imidoylbenzotriazoles 6a-w (56-95%) have also been developed using microwave irradiation under mild conditions and short reaction times. These results demonstrate further the advantages of microwave synthesis and introduce a new application of imidoylbenzotriazoles in the preparation of polysubstituted amidines.