6278-95-1

Upstream product

• 4927-43-9 5-benzyl-5-phenylimidazolidine-2,4-dione 
• 84570-35-4 (3S,6S)-3-Benzyl-6-tert-butyl-3,6-dihydro-5-methoxy-3-phenyl-2H-1,4-oxazin-2-on 
• 84569-96-0 N-(2-Acetoxy-3-methylbutanoyl)phenylglycin 
• 84570-21-8 (6S)-6-tert-Butyl-3,6-dihydro-5-methoxy-3-phenyl-2H-1,4-oxazin-2-on 
• 100-52-7 benzaldehyde 
• 73872-14-7 (2S,4'S,5'S)-(+)-2-Amino-N-(2',2'-dimethyl-4'-phenyl-1',3'-dioxan-5'-yl)-2-phenylacetonitril 
• 2835-06-5 phenylglycin 
• 100-39-0 benzyl bromide 
• 84570-29-6 (3S,6S)-3-Benzyl-3,6-dihydro-6-isopropyl-5-methoxy-3-phenyl-1,4-oxazin-2-on 
• 117470-84-5 2-{[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-amino}-3-phenyl-propionic acid ethyl ester 
• 84570-30-9 (3S,6S)-3-Benzyl-5-ethoxy-3,6-dihydro-6-isopropyl-3-phenyl-2H-1,4-oxazin-2-on 
• 84570-19-4 (6S)-5-Ethoxy-3,6-dihydro-6-isopropyl-3-phenyl-2H-1,4-oxazin-2-on 
• 84570-03-6 ((S)-2-Hydroxy-3-methyl-butyrylamino)-phenyl-acetic acid 
• 84570-10-5 (6S)-6-Isopropyl-3-phenyl-1,4-morpholin-2,5-dion 

Relevant academic research and scientific papers

Enantioselective Synthesis of α-Quaternary Amino Acids by Alkylation of Deprotonated α-Aminonitriles

A series of α-quaternary arylglycines were prepared in high optical purity (up to 98% ee) by α-alkylation of deprotonated α-aminonitriles derived by the Strecker reaction from (4S,5S)-5-amino-2,2-dimethyl-4-phenyl-1,3-dioxane. The procedure includes only chromatographic purification of the final products and is devoid of chromatography or crystallization operations on intermediates to raise the optical purity.