6281-57-8

Basic information

• Product Name: 1-Benzoyl-3-(2,5-dichlorophenyl)thiourea
• Synonyms: 1-Benzoyl-3-(2,5-dichlorophenyl)thiourea;USAF K-1466;N-[(2,5-dichlorophenyl)carbamothioyl]benzamide
• CAS NO: 6281-57-8
• Molecular Formula: C₁₄H₁₀Cl₂N₂OS
• Molecular Weight: 325.213
• Mol File: 6281-57-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.461g/cm³
• Refractive Index: 1.701
• CAS DataBase Reference: 1-Benzoyl-3-(2,5-dichlorophenyl)thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzoyl-3-(2,5-dichlorophenyl)thiourea(6281-57-8)
• EPA Substance Registry System: 1-Benzoyl-3-(2,5-dichlorophenyl)thiourea(6281-57-8)

Safety Data

• Hazardous Substances Data: 6281-57-8(Hazardous Substances Data)

Usage

Appearance

White crystalline solid

Solubility

Soluble in organic solvents

Uses

Pesticide and herbicide

Mechanism of action

Inhibits photosynthesis in plants, leading to their eventual death

InChI:InChI=1/C14H10Cl2N2OS/c15-10-6-7-11(16)12(8-10)17-14(20)18-13(19)9-4-2-1-3-5-9/h1-8H,(H2,17,18,19,20)

Upstream product

• 95-82-9 2,5 dichloroaniline 
• 1147550-11-5 ammonium thiocyanate 
• 98-88-4 benzoyl chloride 
• 532-55-8 Benzoyl isothiocyanate 
• 65-85-0 benzoic acid 

Downstream Products

• 4949-85-3 (2,5-dichlorophenyl)thiourea 
• 108107-58-0 C₂₄H₁₄Cl₂N₄O₃S 
• 108107-59-1 C₂₅H₁₆Cl₂N₄O₃S 
• 108107-60-4 C₂₄H₁₃Cl₃N₄O₃S 
• 108107-61-5 C₂₅H₁₆Cl₂N₄O₄S 
• 69347-87-1 1-(2,5-dichlorophenyl)-2-methylisothiouronium iodide 

Relevant articles and documents

Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds

Two series of compounds carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivatives. The biological results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series (compounds 2.6 and 4.6) on several cell lines tested. Moreover, our results point out an antiangiogenic activity of these compounds. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.

New supramolecular ferrocenyl phenylguanidines as potent antimicrobial and DNA-binding agents

Six new ferrocenyl phenylguanidines have been synthesized and characterized by elemental analysis, FT-IR, multinuclear (1H and 13C) NMR, and single crystal analysis. The latter showed a supramolecular structure for 2 mediated by O H and π H interactions. A subsequent DNA-binding study of these complexes proved them to be good DNA binders with the binding constant varying in the range of 1.2-5.6×105M-1. These compounds were found to have moderate antibacterial and significant antifungal activities, especially for compounds having a chlorophenyl. These compounds may emerge as a new class of anticancer and antifungal agents alone or in combination with other drugs.

Potential antithyroid agent. V. Synthetic and pharmacological studies on some N-aryl-N'-benzoylthiocarbamides

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