62829-72-5Relevant academic research and scientific papers
1-phenothiazinyl-3-aryl-4-acetyl-1, 5-hexanedione and preparation method thereof
-
Paragraph 0083-0086, (2017/10/07)
The invention provides 1-phenothiazinyl-3-aryl-4-acetyl-1, 5-hexanedione and a preparation method thereof. The 1-phenothiazinyl-3-aryl-4-acetyl-1, 5-hexanedione adopts the structural formula as follows: FORMULA. The preparation method comprises the following steps: adding 1-phenothiazinyl-3-aryl-propenone, a catalyst and acetylacetone into a dry mortar, grinding, reacting, performing TLC tracking detection until a reaction is complete, then washing by using water, performing suction filtration, and drying a filter cake to obtain the 1-phenothiazinyl-3-aryl-4-acetyl-1, 5-hexanedione. The preparation method has the advantages of a short reaction time, no solvent, environment friendliness, economy, simple operation, mild reaction conditions, simple post-treatment and high yield. The prepared 1-phenothiazinyl-3-aryl-4-acetyl-1, 5-hexanedione includes a series of brand-new phenothiazinyl-containing ketone derivatives, has sterilizing and bacteriostatic effects and the like, and has a very good application prospect in the antibacterial and anti-virus fields and the like.
Synthesis and psychotropic evaluation of some new N-substitutedbenzothia/ oxazepinylphenothiazines
Bajaj, Kiran,Srivastava,Kumar, Ashok
, p. 157 - 161 (2007/10/03)
A number of N-[2-substitutedaryl-3-substitutedarylaminomethylene-2, 3-dihydro-1,5-benzothia/oxazepin-4-yl]phenothiazines 4a-p and 4a′-p′ have been synthesized from N-[2-substitutedaryl-2, 3-dihydro-1, 5-benzothia/oxazepin-4-yl]phenothiazines by Mannich reaction, on the 3 rd position of benzothia/oxazepine ring. The structure of these compounds have been confirmed by IR, 1H NMR and Mass analysis. The newly synthesized compounds have been evaluated for their psychotropic activities and acute toxicity studies. Compound 4i is found to be most potent compound of this series.
