62838-65-7

Usage

Uses

Used in Pharmaceutical Industry:
2(1H)-Pyridinone, 3-acetyl(9CI) is used as a synthetic intermediate for the development of pharmaceutical compounds. Its ability to form 2,3-disubstituted pyridines and quinolones allows for the creation of a wide range of bioactive molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2(1H)-Pyridinone, 3-acetyl(9CI) is utilized as a key component in the synthesis of various agrochemicals, such as insecticides, herbicides, and fungicides. Its role in creating diverse pyridine-based structures contributes to the development of effective and targeted pest control solutions.
Used in Organic Synthesis:
2(1H)-Pyridinone, 3-acetyl(9CI) is employed as a general chemical reagent in organic synthesis, enabling the formation of complex molecular structures through its reactivity and functional group compatibility. This makes it a valuable tool for researchers and chemists working on the development of new compounds and materials.

InChI:InChI=1/C7H7NO2/c1-5(9)6-3-2-4-8-7(6)10/h2-4H,1H3,(H,8,10)

Upstream product

• 350-03-8 methyl-3-pyridylketone 
• 14188-94-4 3-acetylpyridine N-oxide 
• 131674-39-0 2-chloro-3-(1-hydroxyethyl)pyridine 
• 109-09-1 2-chloropyridine 
• 108-24-7 acetic anhydride 
• 145143-32-4 2-(phenylmethoxy)-3-<(trimethylsilyl)ethynyl>pyridine 
• 55676-21-6 3-acetyl-2-chloropyridine 
• 52200-49-4 3-bromo-2-(phenylmethoxy)pyridine 

Downstream Products

• 1422462-43-8 2-(3',4'-dihydroxyphenyl)-3-hydroxy-4H-pyrano[2,3-b]pyridine-4-one 
• 1422462-39-2 2-(3',4'-dibenzyloxyphenyl)-3-hydroxy-4H-pyrano[2,3-b]pyridine-4-one 

Relevant academic research and scientific papers

A nitrogen oxide C2 - bit hydroxylated method (by machine translation)

The present invention relates to nitrogen oxide C2 - bit hydroxylated method, in particular under reflux conditions in dichloroethane, three pyrrole alkyl bromide (PyBrop) [...] phosphate, sodium acetate, water and nitrogen oxides produced by the reaction of hydroxyl-substituted product. The process has simple operation, mild condition, high reaction selectivity, substrate wide applicability, high yield and the like. The application for the first time using this method to synthesize a series of 2 - hydroxyquinoline, 2 - hydroxy pyridine and 1 - hydroxy isoquinoline compound, in the establishment of the compounds of the library synthesis application have broad prospects. (by machine translation)

CHROMAN - SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS

The invention relates to chroman spirocyclic piperidine amide derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Novel synthesis of tetrahydro-2(1H)-quinolones using Diels-Alder reactions of 1-arylsulfonyl-2(1H)-pyridones having an electron-withdrawing group

A novel synthetic methodology of preparing tetrahydro-2(1H)-quinolones by Diels-Alder reactions between 2-methyl- and 2,3-dimethyl-1,3-butadienes and 1-arylsulfonyl-2(1H)-pyridones having an electron-withdrawing group at the 5-position is presented. Furthermore, the site-selectivity analyses based on MO calculations of the 5-substituted 2(1H)-pyridones acting as the dienophiles are described.

Use of Hydrogen Bonds to Control Molecular Aggregation. Behavior of a Self-Complementary Dipyridone Designed to Self-Replicate

In principle, the simple dipyridone 4 encodes enough chemical information to allow it to self-replicate by acting as a template for the assembly and controlled oxidative coupling of ethynylpyridone subunits 5 and 6.This could occur by the formation of ter

Improved Synthesis of 2,3-Disubstituted Pyridines by Metallation of 2-Chloropyridine: a Convenient Route to Fused Polyheterocycles

Chemoselective directed metallation of 2-chloropyridine allows the synthesis of 2-substituted 3-carbonylated pyridines, advantage being taken of the metallation ortho-directing effect of the halogen, as well as its reactivity towards nucleophiles.Thus (2-chloro-, 2-methoxy-, and 2-amino-3-pyridyl)-ethanones and -arylmethanones as well as carbaldehydes have been prepared.Some of these ortho-disubstituted intermediates have been readily cyclized to fused polyheterocycles such as naphthiridines and aza-analoges of coumarins, xanthones, and acridones.

OXYGENATION OF THE UNACTIVATED PYRIDINE SYSTEM BY ACETYL HYPOFLUORITE MADE DIRECTLY FROM F2

Acetyl hypofluorite was found capable of activating the usually unreactive pyridine by substituting the hydrogen at the 2 position by an acetoxy group which then was hydrolyzed to the corresponding pyridinone.Substitutents at 3, 4 or 5 position do not interfere with the reaction, but compounds with substituents at 2 (with the exception of aromatic ones) either do not react or produce tars.The reaction conditions are very mild and the yields are very good for this kind of substitution.Quinolines and pyrazines also react very satisfactorily.