14188-94-4

Basic information

• Product Name: 1-(1-Oxido-3-pyridinyl)-ethanone
• Synonyms: Ethanone, 1-(1-oxido-3-pyridinyl)- (9CI);3-Acetylpyridine N-oxide;1-(1-oxidopyridin-1-ium-3-yl)ethanone;3-Acetylpyridine N-Oxide
• CAS NO: 14188-94-4
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 138.14392
• Product Categories: ACETYLGROUP
• Mol File: 14188-94-4.mol
• Article Data: 16

Chemical Properties

• Melting Point: 144.0 to 148.0 °C
• Boiling Point: 347.3 °C at 760 mmHg
• Flash Point: 163.8 °C
• Appearance: /
• Density: 1.13 g/cm³
• Vapor Pressure: 5.44E-05mmHg at 25°C
• Refractive Index: 1.535
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: 1-(1-Oxido-3-pyridinyl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-Oxido-3-pyridinyl)-ethanone(14188-94-4)
• EPA Substance Registry System: 1-(1-Oxido-3-pyridinyl)-ethanone(14188-94-4)

Safety Data

• Hazardous Substances Data: 14188-94-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(1-Oxido-3-pyridinyl)-ethanone is used as an intermediate in the synthesis of Nilotinib N-Oxide (N465310), which is a metabolite of the drug Nilotinib (N465300). This application is significant because Nilotinib is a tyrosine kinase inhibitor used in the treatment of certain types of cancer, such as chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). By facilitating the synthesis of its metabolite, 1-(1-Oxido-3-pyridinyl)-ethanone plays a vital role in the development and production of life-saving medications.

InChI:InChI=1/C7H7NO2/c1-6(9)7-3-2-4-8(10)5-7/h2-5H,1H3

Upstream product

• 350-03-8 methyl-3-pyridylketone 
• 14906-62-8 3-ethylpyridine N-oxide 
• 7664-93-9 sulfuric acid 
• 64-19-7 acetic acid 

Downstream Products

• 249583-84-4 5-acetyl-2-pyridinecarbonitrile 
• 1357481-47-0 (E)-3-(1-(2-(4-methylphenylsulfonyl)hydrazono)ethyl)pyridine 1-oxide 
• 232602-14-1 1-(2-benzyl-pyridin-3-yl)-ethanone 
• 1394029-21-0 (4'-isopropoxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3-b]pyridine]-1-yl)(4-isopropoxy-3-methylphenyl)methanone 
• 1394030-86-4 (4'-hydroxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3-b]pyridine]-1-yl)(4-isopropoxy-3-methylphenyl)methanone 
• 1394030-85-3 1-(4-isopropoxy-3-methylbenzoyl)spiro[piperidine-4,2'-pyrano[2,3-b]pyridin]-4'(3'H)-one 
• 62838-65-7 1-(2-hydroxypyridin-3-yl)ethanone 
• 1124-29-4 5-acetylpyridin-2(1H)-one 
• 5096-11-7 (S)-3-(1-hydroxyethyl)pyridine 
• 116835-06-4 1-(2,4-Dinitro-phenyl)-3-methyl-5-nitro-1H-pyrazolo[3,4-b]pyridine 
• 116855-13-1 2-(2,4-Dinitro-phenyl)-3-methyl-2H-pyrazolo[3,4-b]pyridine 
• 116835-05-3 1-(2,4-Dinitro-phenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine 
• 116855-09-5 1-methylpyrazolo<3,4-b>pyridine-3-carboxylic acid 
• 116855-08-4 1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid 

Relevant articles and documents

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