14188-94-4

Basic information

• Product Name: 1-(1-Oxido-3-pyridinyl)-ethanone
• Synonyms: Ethanone, 1-(1-oxido-3-pyridinyl)- (9CI);3-Acetylpyridine N-oxide;1-(1-oxidopyridin-1-ium-3-yl)ethanone;3-Acetylpyridine N-Oxide
• CAS NO: 14188-94-4
• Molecular Formula: C₇H₇NO₂
• Molecular Weight: 138.14392
• Product Categories: ACETYLGROUP
• Mol File: 14188-94-4.mol
• Article Data: 16

Chemical Properties

• Melting Point: 144.0 to 148.0 °C
• Boiling Point: 347.3 °C at 760 mmHg
• Flash Point: 163.8 °C
• Appearance: /
• Density: 1.13 g/cm³
• Vapor Pressure: 5.44E-05mmHg at 25°C
• Refractive Index: 1.535
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: 1-(1-Oxido-3-pyridinyl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-Oxido-3-pyridinyl)-ethanone(14188-94-4)
• EPA Substance Registry System: 1-(1-Oxido-3-pyridinyl)-ethanone(14188-94-4)

Safety Data

• Hazardous Substances Data: 14188-94-4(Hazardous Substances Data)

Usage

Uses

3-Acetylpyridine N-Oxide is an intermediate in synthesizing Nilotinib N-Oxide (N465310), which is a metabolite of Nilotinib (N465300).

InChI:InChI=1/C7H7NO2/c1-6(9)7-3-2-4-8(10)5-7/h2-5H,1H3

Upstream product

• 350-03-8 methyl-3-pyridylketone 
• 14906-62-8 3-ethylpyridine N-oxide 
• 7664-93-9 sulfuric acid 
• 64-19-7 acetic acid 

Downstream Products

• 109510-51-2 3-acetyl-1-methoxy-pyridinium; (toluene-4-sulfonate) 
• 84499-26-3 3-acetyl-1-(p-nitrophenoxy)pyridinium tetrafluoroborate 
• 350-03-8 methyl-3-pyridylketone 
• 55676-21-6 3-acetyl-2-chloropyridine 
• 62838-65-7 1-(2-hydroxypyridin-3-yl)ethanone 
• 1124-29-4 5-acetylpyridin-2(1H)-one 
• 1394030-85-3 1-(4-isopropoxy-3-methylbenzoyl)spiro[piperidine-4,2'-pyrano[2,3-b]pyridin]-4'(3'H)-one 
• 1394030-86-4 (4'-hydroxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3-b]pyridine]-1-yl)(4-isopropoxy-3-methylphenyl)methanone 
• 1394029-21-0 (4'-isopropoxy-3',4'-dihydrospiro[piperidine-4,2'-pyrano[2,3-b]pyridine]-1-yl)(4-isopropoxy-3-methylphenyl)methanone 
• 232602-14-1 1-(2-benzyl-pyridin-3-yl)-ethanone 
• 1357481-47-0 (E)-3-(1-(2-(4-methylphenylsulfonyl)hydrazono)ethyl)pyridine 1-oxide 
• 249583-84-4 5-acetyl-2-pyridinecarbonitrile 
• 5096-11-7 (S)-3-(1-hydroxyethyl)pyridine 
• 116835-06-4 1-(2,4-Dinitro-phenyl)-3-methyl-5-nitro-1H-pyrazolo[3,4-b]pyridine 

Relevant articles and documents

A practical, efficient, and rapid method for the oxidation of electron deficient pyridines using trifluoroacetic anhydride and hydrogen peroxide- urea complex

A general method for the oxidation of electron-poor pyridines to their N-oxides using UHP and TFAA in either CH2Cl2 or CH3CN was developed. The methodology proved to tolerate a number of functional groups and substitution

A lipase-glucose oxidase system for the efficient oxidation of: N -heteroaromatic compounds and tertiary amines

In this work, a lipase-glucose oxidase system has been designed and proven to be an efficient system for the oxidation of N-heteroaromatic compounds and tertiary amines. This dual-enzyme system not only displays environmental friendliness, but also demonstrates its huge potential in industrial applications.

Grafting of a rhenium-oxo complex on Schiff base functionalized graphene oxide: An efficient catalyst for the oxidation of amines

A rhenium-oxo complex such as methyltrioxorhenium (MTO) has been homogeneously immobilized on a Schiff base modified graphene oxide (GrO) support via covalent bonding. The loading of MTO on GrO nanosheets was monitored by FTIR, TG-DTA, and elemental analyses. The developed heterogeneous catalyst is found to be efficient for the oxidation of various amines to the corresponding N-oxides using hydrogen peroxide as an oxidant in high to excellent yields. At the end of the reaction, the catalyst is readily recovered by filtration and reused for subsequent runs. After the third run, the catalyst showed a marginal decrease in catalytic activity owing to the leaching of the MTO complex from the support. This journal is the Partner Organisations 2014.