6287-88-3Relevant academic research and scientific papers
Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives
Hansen, Finn K.,Khankischpur, Mehdi,Tolaymat, Ibrahim,Mesaros, Renata,Dannhardt, Gerd,Geffken, Detlef
experimental part, p. 5031 - 5034 (2012/08/28)
A series of 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives has been prepared and subsequently evaluated with regards to the inhibition of 5-LOX/COX. Structure optimization furnished derivatives with promising in vitro activity as dual 5-LOX/COX inhibitors with submicromolar IC50 values for inhibition of 5-LOX and COX-1, respectively.
A convenient synthesis of benzothiophene derivatives
Cabiddu, M.Grazia,Cabiddu, Salvatore,Cadoni, Enzo,Demontis, Stefania,Fattuoni, Claudia,Melis, Stefana
, p. 4529 - 4533 (2007/10/03)
(Methylthio)- and 2-bromo-1-(methylthio)benzene are useful synthons to prepare monometallated and bimetallated intermediates which lead to 1-benzothiophenes functionalized in the three and/or two positions.
Novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles as potential antiallergy agents
Connor,Cetenko,Mullican,Sorenson,Unangst,Weikert,Adolphson,Kennedy,Thueson,Wright,Conroy
, p. 958 - 965 (2007/10/02)
The synthesis and antiallergic activity of a series of novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles are described. A number of the compounds inhibit the release of histamine from anti-IgE stimulated basophils obtained from alle
3-Alkoxy-thianapthene-2-carboxamides
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, (2008/06/13)
The 3-alkoxy-thianaphthene-2-carboxamides of this invention are effective for the treatment of mammals afflicted with emesis. When administered to dogs in dosages of 250 μg/kg, compounds of this invention give 100% protection against vomiting normally induced by subcutaneous administration of apomorphine. The compounds of this invention also favorably modify behavior disturbances in mammals.
