62882-08-0

Basic information

• Product Name: 2-(4-NITROPHENYL)OXAZOLE 97
• Synonyms: 2-(4-NITROPHENYL)OXAZOLE 97
• CAS NO: 62882-08-0
• Molecular Formula: C₉H₆N₂O₃
• Molecular Weight: 190.157
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Oxazoles
• Mol File: 62882-08-0.mol

Chemical Properties

• Melting Point: 163.5-164.5 °C
• Boiling Point: 346.23°C at 760 mmHg
• Flash Point: 163.194°C
• Appearance: /
• Density: 1.334g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: Room temperature.
• PKA: -0.78±0.10(Predicted)
• CAS DataBase Reference: 2-(4-NITROPHENYL)OXAZOLE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-NITROPHENYL)OXAZOLE 97(62882-08-0)
• EPA Substance Registry System: 2-(4-NITROPHENYL)OXAZOLE 97(62882-08-0)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 62882-08-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-(4-Nitrophenyl)oxazole 97 is used as a reagent in organic synthesis for its ability to facilitate the creation of various organic compounds. Its unique structure and properties make it a versatile component in the synthesis process.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-(4-Nitrophenyl)oxazole 97 is used as a key intermediate in the development of new drugs. Its chemical properties allow for the exploration of novel therapeutic agents and contribute to the advancement of medicinal chemistry.
Used in Agrochemical Production:
2-(4-Nitrophenyl)oxazole 97 is utilized in the production of agrochemicals, where it serves as a building block for the synthesis of compounds with pesticidal or herbicidal properties, contributing to the development of effective crop protection agents.
Used in Dye Manufacturing:
In the dye industry, 2-(4-Nitrophenyl)oxazole 97 is used as a component in the production of dyes, taking advantage of its yellow crystalline color to create a variety of colorants for different applications.
Used in Materials Science:
2-(4-Nitrophenyl)oxazole 97 is employed in materials science for its potential applications in the development of new materials with unique properties, such as those with enhanced stability or specific interactions with other molecules.

InChI:InChI=1/C9H6N2O3/c12-11(13)8-3-1-7(2-4-8)9-10-5-6-14-9/h1-6H

Upstream product

• 7465-63-6 2-(4-Nitrophenyl)-4,5-dihydrooxazole 
• 20662-88-8 2-phenyloxazole 
• 7664-93-9 sulfuric acid 
• 93-89-0 benzoic acid ethyl ester 
• 555-16-8 4-nitrobenzaldehdye 
• 645-36-3 2,2-diethoxy-ethanamine 
• 1064706-46-2 2-(4-nitrophenyl)-4,5-dihydro-5-diethylsulfonamideoxazole 
• 619-72-7 4-nitrobenzonitrile 
• 586-78-7 para-nitrophenyl bromide 
• 609345-33-7 oxazol-2-ylzinc(II) chloride 
• 636-98-6 p-nitrobenzene iodide 
• 18838-10-3 N-(2-hydroxyethyl)-benzamide 
• 7127-19-7 2-phenyl-1,3-oxazoline 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 62882-11-5 4-(1,3-oxazol-2-yl)aniline 
• 126193-97-3 N-(p-nitrobenzoyl)-1,2,2-trimethoxyethyl amine 
• 20662-88-8 2-phenyloxazole 
• 860542-34-3 N-acetyl-sulfanilic acid-(4-oxazol-2-yl-anilide) 

Relevant articles and documents

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

DDQ-induced dehydrogenation of heterocycles for c-c double bond formation: Synthesis of 2-thiazoles and 2-oxazoles

Strong as an Ox: 2-Thiazoles and 2-oxazoles are formed by oxidation of 2-thiazolines and 2-oxazolines without requiring substituents at the C4 and C5 positions. DDQ plays an important role as the oxidant in this transformation and metal is unnecessary. This general procedure shows good functional group tolerance and provides a wide variety of 2-thiazoles and 2-oxazoles in moderate to excellent yields.

A versatile synthesis of 2,4-substituted oxazoles

A variety of five-membered ring oxazoles have been synthesised with complete regiocontrol and without the requirement for ring oxidation via a reaction sequence based on a vinyl sulfonamide template. The Royal Society of Chemistry.

ANTIFUNGAL AGENTS

Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents: (I) wherein: Rl, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (T), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

Anodic methoxylation and acetoxylation of imines and imidates

Anodic oxidation of cyclic imidates, 2-aryl-2-oxazolines, in methanol provided the corresponding 4-methoxylated products. Anodic α-methoxylation and α-acetoxylation of open-chain imines derived from glycine esters and benzophenone were also achieved using a bromide ion mediator. On the other hand, anodic α-acetoxylation of CF3-containing imine and imidate was successful without use of the bromine mediator. This is the first example of successful anodic α-substitution of imines and imidates.

An improved method for the palladium cross-coupling reaction of oxazol-2-ylzinc derivatives with aryl bromides

An improved and scalable procedure to couple ozaxole and thiazole to aryl halides has been demonstrated. The required organozinc reagents were prepared from the aryllithium and solid ZnCl2. These reagents have been successfully coupled to a variety of aryl bromides and aryl iodides in good to excellent yields.

Preparation of 2-substituted oxazoles

A simple and economical method for 2-substituted oxazole synthesis and its scope are described.

SYNTHESIS AND SOME ELECTROPHILIC SUBSTITUTION REACTIONS OF 2-PHENYLOXAZOLE

A new synthesis of 2-phenyloxazole that includes the preparation of 2-phenyloxazoline and aromatization of the latter by the action of nickel peroxide was developed.It was established that under conditions that exclude protonation electrophilic substituti