62883-00-5

Basic information

• Product Name: Iopamidol
• Synonyms: N,N'-BIS(1,3-DIHYDROXYPROPAN-2-YL)-5-(2-HYDROXYPROPANOYLAMINO)-2,4,6-TRIIODO-BENZENE-1,3-DICARBOXAMIDE;Iopamidol;N,N'-Bis(2-hydroxy-1-(hydroxymethyl)ethyl)-5-((2-hydroxy-1-oxopropyl)amino)-2,4,6-triiodo-1,3-Benzenedicarboxamide;1-N,3-N-bis(1,3-dihydroxypropan-2-yl)-5-(2-hydroxypropanoylamino)-2,4,6-triiodobenzene-1,3-dicarboxamide;N,N'-bis(2-hydroxy-1-methylol-ethyl)-2,4,6-triiodo-5-lactamido-isophthalamide;N1,N3-bis(1,3-dihydroxypropan-2-yl)-5-(2-hydroxypropanoylamino)-2,4,6-triiodo-benzene-1,3-dicarboxamide;1,3-BenzenedicarboxaMide,N1,N3-bis[2-hydroxy-1-(hydroxyMethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)aMino]-2,4,6-triiodo-
• CAS NO: 62883-00-5
• Molecular Formula: C17H22I3N3O8
• Molecular Weight: 777.09
• EINECS: 262-093-6
• Product Categories: Other APIs
• Mol File: 62883-00-5.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 785.3 °C at 760 mmHg
• Flash Point: 428.8 °C
• Appearance: /
• Density: 2.281 g/cm³
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Water (Slightly)
• PKA: pKa 10.70(H2O,t = 25.0) (Uncertain)
• CAS DataBase Reference: Iopamidol(CAS DataBase Reference)
• NIST Chemistry Reference: Iopamidol(62883-00-5)
• EPA Substance Registry System: Iopamidol(62883-00-5)

Safety Data

• Hazardous Substances Data: 62883-00-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 62883-00-5 differently. You can refer to the following data:
1. Diagnostic aid (radiopaque medium.
2. Iopamidol (CAS# 60208-45-9) is a radiological nonionic medical contrast agent.

Upstream product

• 60166-91-8 S-(-)-5-[[2-(acetyloxy)-1-oxopropyl]amino]-2,4,6-triiodo-1,3-benzenedicarboxylic acid dichloride 
• 534-03-2 serinol 
• 618-88-2 5-nitrobenzene-1,3-dicarboxylic acid 
• 10552-75-7 dibutyl 5-nitroisophthalate 
• 25351-79-5 5-amino-isophthalic acid dibutyl ester 
• 267881-76-5 5-amino-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-1,3-benzenedicarboxamide 
• 60166-98-5 S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-amino-2,4,6-triiodo-1,3-benzenedicarboxamide 
• 35453-19-1 2,4,6-triiodo-5-aminoisophthalic acid 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF IOPAMIDOL

The present invention provides a process for the preparation of a compound of Formula (II) wherein the process comprises: (i) reacting a compound of Formula (I) with pyridine and 2-acetyloxypropanoyl chloride (APC) to give a compound of Formula (II), wherein the compound of Formula (I) has the following structure.

PROCESS FOR THE PREPARATION OF IOPAMIDOL

The present invention discloses a process for the preparation of Iopamidol of formula (II) and comprising the following steps: a) reacting the Compound (I) wherein X is OR2 or R3, and wherein R2 and R3 are a Ci-C6 linear or branched alkyl, C3-C6 cycloalkyl, C6 aryl, optionally substituted with a group selected from the group consisting of methyl, ethyl, n-propyl, i-propyl, n-butyl, sec-butyl, t-butyl and phenyl, with the acylating agent (S)-2-(acetyloxy)propanoyl chloride in a reaction medium to provide the acetyloxy derivative of Compound (I); b) hydrolyzing the intermediate from step a) with an aqueous solution at a pH comprised from 0 to 7, by adding water or a diluted alkaline solution such as sodium hydroxide or potassium hydroxide, freeing the hydroxyls from the boron-containing protective groups, obtaining the N-(S)-2-(acetyloxy)propanoyl derivative of Compound (II); c) alkaline hydrolysis to restore the (S)-2-(hydroxy)propanoyl group and to obtain lopamidol (II) and optional recovery of the boron derivative from the solution obtained in step b). The boron-containing protective group is versatile, efficient and recyclable. A one-pot synthesis, without intermediate isolation is provided, leading to a decreasing of recovered and recycled solvents and a significant increasing in the yield, representing a significant advantage in terms of cost-effectiveness of the entire process and environmental awareness.

Process For The Preparation Of Contrast Agents

The present invention relates to a process for the preparation of 5-[(2-hydroxyacyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamidic derivatives comprising the Smiles rearrangement of a suitable precursor, by contact of an aqueous solution of this latter with an anion exchanger solid phase.