62894-01-3

Upstream product

• 556-82-1 3-methyl-2-buten-1-ol 
• 18511-56-3 (3,3-dimethyloxiranyl)methanol 
• 98-88-4 benzoyl chloride 
• 5205-11-8 3-methyl-2-butenyl benzoate 

Downstream Products

• 138240-07-0 Benzoic acid 2,3-dihydroxy-3-methyl-butyl ester 
• 138240-13-8 Benzoic acid 2,3-dihydroxy-1,1-dimethyl-propyl ester 
• 138240-10-5 Benzoic acid 2-hydroxy-1-hydroxymethyl-2-methyl-propyl ester 
• 1206588-63-7 2-hydroxy-3-methylbut-3-en-1-yl benzoate 
• 1242418-53-6 C₁₂H₁₅⁽²⁾HO₃ 
• 235432-83-4 C₁₂H₁₆O₃ 
• 138240-14-9 2t-Allyl-4r-(hydroxymethyl)-2c-phenyl-1,3-dioxolane 
• 138240-14-9 2c-Allyl-4r-(hydroxymethyl)-2t-phenyl-1,3-dioxolane 

Relevant academic research and scientific papers

Proton-accelerated Lewis acid catalysis for stereo- And regioselective isomerization of epoxides to allylic alcohols

The isomerization of epoxides to allylic alcohols was developedviaproton-accelerated Lewis acid catalysis. The addition oftBuOH as a proton source is the key to the efficient catalytic cycle. Trisubstituted epoxides, including enantioenriched derivatives, were selectively converted to secondary-allylic alcohols without loss of enantiopurity.

Total Synthesis of (-)-Nemorosone and (+)-Secohyperforin

A general strategy for the synthesis of polycyclic polyprenylated acylphloroglucinols is described in which a scalable, Lewis acid catalyzed epoxide-opening cascade cyclization is used to furnish common intermediate 4. The utility of this approach is exemplified by the total syntheses of both ent-nemorosone and (+)-secohyperforin, which were each accomplished in four steps from this intermediate.

ANTIDIABETIC TRICYCLIC COMPOUNDS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

Radical reduction of epoxides using a titanocene(III)/water system: Synthesis of β-deuterated alcohols and their use as internal standards in food analysis

We describe a comprehensive study into the Cp2TiCl-mediated reductive epoxide ring opening using either water as a hydrogen source or deuterium oxide as a deuterium source. The remarkable chemical profile of this reaction allows access to alcohols with anti-Markovnikov regiochemistry from different epoxides. The use of D2O as a deuterium source leads to an efficient synthesis of β-deuterated alcohols, including a deuterated sample of tyrosol, a bioactive compound contained in the leaves of the olive, which was successfully applied as an internal standard in food analysis.

Mixed disproportionation versus radical trapping in titanocene(III)-promoted epoxide openings

The formation of either deoxygenation products or allylic alcohols from epoxides is observed when these substrates are treated with Cp2TiCl under anhydrous conditions. It seems that processes via trisubstituted radicals give allylic alcohols whereas processes via disubstituted radicals may give deoxygenation products or allylic alcohols depending on the structure of the original epoxide. This method allows a controlled access to these functional groups, providing a useful tool in organic synthesis. A mechanistic discussion for these transformations is reported.

Direct Epoxidation of Olefins Catalyzed by Nickel(II) Complexes with Molecular Oxygen and Aldehydes

The presence of a bis(1,3-diketonato)nickel(II) complex, various olefins are directly monooxygenated into the corresponding epoxides on treatment with atmospheric pressure of oxygen or air and aldehydes.Especially, it is noted that bisnickel(II) behaves as an excellent catalyst in the present epoxidation.

Aerobic Oxygenation of Olefinic Compounds into the Corresponding α-Hydroxy Ketones Using the Catalyst System of OsO4 and Ni(II) Complex

In the presence of the catalyst system of OsO4 and bis(3-methyl-2,4-pentanedionato)nickel(II), various olefinic compounds are directly converted into the corresponding α-hydroxy ketones in good yields with molecular oxygen and an aldehyde.