62928-94-3

Basic information

• Product Name: (1,2,3,4-tetrahydro-isoquinolin-3-yl)-methanol
• Synonyms: (1,2,3,4-TETRAHYDRO-ISOQUINOLIN-3-YL)-METHANOL
• CAS NO: 62928-94-3
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.22
• Mol File: 62928-94-3.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 307.9 °C at 760 mmHg
• Flash Point: 147 °C
• Appearance: /
• Density: 1.081 g/cm³
• CAS DataBase Reference: (1,2,3,4-tetrahydro-isoquinolin-3-yl)-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1,2,3,4-tetrahydro-isoquinolin-3-yl)-methanol(62928-94-3)
• EPA Substance Registry System: (1,2,3,4-tetrahydro-isoquinolin-3-yl)-methanol(62928-94-3)

Safety Data

• Hazardous Substances Data: 62928-94-3(Hazardous Substances Data)

Usage

General Description

(1,2,3,4-Tetrahydro-isoquinolin-3-yl)-methanol, also known as THIQ-methanol, is a chemical compound with potential applications in the pharmaceutical industry. It is a derivative of tetrahydroisoquinoline, which is a building block for various bioactive molecules. THIQ-methanol has been studied for its potential as a building block in the synthesis of novel pharmaceutical compounds. It has also been investigated for its potential therapeutic effects, particularly in the treatment of addiction and neurological disorders. Additionally, it has been explored as a precursor for the production of various organic compounds. Studies have shown that THIQ-methanol exhibits promising pharmacological properties, making it an interesting compound for further research and development in the pharmaceutical field.

Upstream product

• 63-91-2 L-phenylalanine 
• 1510832-00-4 (S)-(2-((4-nitrophenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methanol 
• 62708-42-3 o-allylbenzaldehyde 
• 79815-19-3 methyl (3S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate 
• 15912-55-7 ethyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 67123-97-1 (R,S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 77497-95-1 (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride 
• 74163-81-8 L-Tic-OH 
• 15912-56-8 ethyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride 
• 77497-96-2 (S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, phenylmethylester 
• 50-00-0 formaldehyd 
• 63-91-2 L-phenylalanine 

Downstream Products

• 866186-93-8 N-[2-(3-hydroxymethyl-3,4-dihydro-1H-isoquinolin-2-yl)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]-2-nitro-benzenesulfonamide 
• 183958-71-6 tert-butyl (3S)-3-(hydroxymethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 102125-88-2 2-((S)-2-Benzyloxycarbonyl-1-hydroxy-4-oxo-1,3,4,6,11,11a-hexahydro-2H-pyrazino[1,2-b]isoquinolin-3-ylmethyl)-malonic acid dimethyl ester 
• 102125-84-8 C₂₆H₂₆N₂O₇ 
• 195832-14-5 S-3-hydroxymethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester 
• 1018826-57-7 (S)-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methanol 
• 1124157-92-1 C₃₄H₂₉BrN₄O₃ 
• 1124157-94-3 C₃₄H₂₉ClN₄O₃ 
• 1124157-98-7 C₂₆H₂₉BrN₄O₃ 
• 1124158-00-4 C₂₆H₂₃ClF₆N₄O₃ 
• 1124158-04-8 C₃₀H₃₇ClN₄O₃ 
• 1124157-41-0 C₃₄H₃₀N₄O₃ 
• 1510832-00-4 (S)-(2-((4-nitrophenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)methanol 
• 914083-31-1 Sulfamic acid (S)-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethyl ester 

Relevant articles and documents

Stereoselective synthesis of 1,3-disubstituted dihydroisoquinolines vial-phenylalanine-derived dihydroisoquinoline N-oxides

The preparation of chiral pool-derived nitrone 3 and its use in the protecting-group free, stereoselective synthesis of a range of 1,3-disubstituted tetrahydroisoquinolines is described. Grignard reagent additions to nitrone 3 yielded trans-1,3-disubstituted N-hydroxytetrahydroisoquinolines 6 with good levels of selectivity, while 1,3-dipolar cycloadditions to this nitrone provided access to 3-(2-hydroxyalkyl)isoquinolines 12 as single diastereomers.

Practical and cost-effective manufacturing route for the synthesis of a β-lactamase inhibitor

Compound 1, a potent and irreversible inhibitor of β-lactamases, is in clinical trials with β-lactam antibiotics for the treatment of serious and antibiotic-resistant bacterial infections. A short, scalable, and cost-effective route for the production of this densely functionalized polycyclic molecule is described.

An organogel formed from a cyclic β-aminoalcohol

A new organogelator with unique structural feature of a cyclic β-aminoalcohol is presented as the first example of gelation by aminoalcohol through hydrogen-bonding between hydroxy and amine.