62935-93-7Relevant academic research and scientific papers
The Ugly Duckling Metamorphosis: The Ammonia/Formaldehyde Couple Made Possible in Ugi Reactions.
Rosalba, Thaissa Pasquali F.,Kas, Samia Sayegh A.,Sampaio, Ana Beatriz S.,Salvador, Carlos Eduardo M.,Andrade, Carlos Kleber Z.
, p. 2831 - 2842 (2021/05/13)
Ugi reactions are still a challenge when the concomitant use of ammonia and formaldehyde is required. Herein, we propose a strategy to overcome this challenge using hexamethylenetetramine (HMTA) as a singular key for the employment of these two simple starting materials in the Ugi reaction. Acylaminoacetamide derivatives were prepared in good to excellent yields by this new methodology. The scope and optimization of the reaction conditions were investigated. This novel methodology was successfully applied in the synthesis of two different diketopiperazines (DKPs) using the Ugi/Deprotection+Activation/Cyclization (UDAC) method. A continuous flow approach was also used in this methodology.
A study of fragmentation of protonated amides of some acylated amino acids by tandem mass spectrometry: Observation of an unusual nitrilium ion
Talaty, Erach R.,Young, Sarah M.,Dain, Ryan P.,Van Stipdonk, Michael J.
experimental part, p. 1119 - 1129 (2012/03/26)
A tandem mass spectrometric study of a series of secondary amides of acetylglycine and hippuric acid utilizing electrospray ionization (ESI) was conducted. Among the fragment ions observed was an unusual one, which we have determined to be a nitrilium ion
