95-96-5

Usage

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C6H8O4/c1-3-5(7)10-4(2)6(8)9-3/h3-4H,1-2H3

Upstream product

• 97-64-3 ethyl 2-hydroxypropionate 
• 79-33-4 L-Lactic acid 
• 10326-41-7 D-Lactic acid 
• 849585-22-4 LACTIC ACID 
• 4511-42-6 L,L-dilactide 
• 13076-19-2 (3R,6S)-3,6-dimethyl-1,4-dioxane-2,5-dione 
• 547-64-8 methyl lactate 
• 123-54-6 acetylacetone 
• 515-98-0 Ammonium lactate 
• 814-80-2 calcium lactate 
• 78024-33-6 2-(2-lactoyloxy-propionyloxy)-propionic acid 
• 65002-62-2 2-lactoyloxy-propionic acid ethyl ester 
• 100053-90-5 lactic acid trimer ethyl ester 
• 673502-34-6 5-acetyl-3,6-dimethyl-2,3-dihydro-1,4-dioxin-2-one 

Downstream Products

• 598-81-2 (+/-)-lactamide 
• 2051-96-9 benzyl lactate 
• 958298-96-9 (N,N'-bis(2,6-diisopropylphenyl)(tert-butyl)amidinato)tin(II)(OCH(Me)C(O)OCH(Me)C(O)OCHMe₂) 
• 1316188-10-9 (C₆F₅)3B(OCOCH(CH₃))2 
• 535-17-1 2-acetoxypropionic acid 
• 6284-75-9 methyl 2-acetoxypropionate 
• 547-64-8 methyl lactate 
• 97-64-3 ethyl 2-hydroxypropionate 
• 616-09-1 n-propyl lactate 
• 57-55-6 propylene glycol 
• 70022-27-4 benzyl dilactate 
• 600-14-6 2,3-Pentanedione 
• 75-07-0 acetaldehyde 
• 950500-94-4 N-(2-hydroxyethyl)-N-benzyl lactamide 

Relevant academic research and scientific papers

A study on highly concentrated lactic acid and the synthesis of lactide from its solution

Lactic acid is an important platform compound used as raw material for the production of lactide and polylactic acid. However, its concentration and composition distribution are not as simple as those of common compounds. In this work, the mass concentration distribution of highly concentrated lactic acid is determined by back titration. The components of highly concentrated lactic acid, crude lactide, and polymer after the reaction are analyzed by HPLC. Different concentrations of lactic acid solution were prepared for the synthesis of lactide and its content in the product was determined by 1H NMR analysis. We found that lactide is more easily produced from high-concentration lactic acid solution with which the condensed water is easier to release. Hence, the removal of condensed water is crucial to the formation of lactide, although it is not directly formed by esterification of two molecules of lactic acid.

Chemical Recycling of End-of-Life Poly(lactide) via Zinc-Catalyzed Depolymerization and Polymerization

The chemical recycling of poly(lactide) was investigated based on depolymerization and polymerization processes. Using methanol as depolymerization reagent and zinc salts as catalyst, poly(lactide) was depolymerized to methyl lactate applying microwave heating. An excellent performance was observed for zinc(II) acetate with turnover frequencies of up to 45000 h?1. In a second step the monomer methyl lactate was converted to (pre)poly(lactide) in the presence of catalytic amounts of zinc salts. Here zinc(II) triflate revealed excellent performance for the polymerization process (yield: 91 %, Mn ～8970 g/mol). Moreover, the (pre)poly(lactide) was depolymerized to lactide, the industrial relevant molecule for accessing high molecular weight poly(lactide), using zinc(II) acetate as catalyst.

METHOD FOR SYNTHESIZING LACTIDE BY MEANS OF CATALYSIS OF LACTID ACID

The present invention relates to a method for the catalytic synthesis of lactide from lactic acid. The method relates to the synthesis of lactide from lactic acid under the catalysis of a zinc oxide nanoparticle aqueous dispersion as a catalyst. The present invention has four technical characteristics: I. the zinc oxide nanoparticle aqueous dispersion catalyst has a sufficient surface area, and the size of nanoparticles is merely 30-40 nm, providing a sufficient contact area between the substrate (lactic acid) and the catalyst; II. the new catalyst has a milder catalytic effect on polymerization, allowing the molecular weight distribution of a prepolymer within a range of 400-1500 g/mol, which is advantageous for depolymerization to proceed; III. the new catalyst is stable, thus avoiding oxidation or carbonization in a high temperature reaction; and IV. the new catalyst has a low toxicity and a small threat to human health.

PROCESS FOR PREPARING A CYCLIC DIESTER OR A CYCLIC DIAMIDE BY REACTING A HYDROXYCARBOXYLIC ACID OR AMIDE WITH AN ACIDIC BEA-TYPE (H-BETA POLYMORPH A) ZEOLITE

A process for preparing a cyclic diester or a cyclic diamide by reacting a hydroxycarboxylic acid or amide with an acidic BEA (H-beta polymorph A) type zeolite. The process is characterised in that the total amount of acid sites is in the range of from 0.25 to 1.0 mmol/g and the amount of medium acid sites is at least 40% of the total amount of acid sites. The total amount of acid sites and the amount of medium acid sites are determined by NH3-TPD (temperature-programmed desorption of ammonia). Preferably, the process refers to the preparation of lactide from lactic acid. The framework structure of the zeolitic material comprises Si, Al, O, and H.

PREPARATION METHOD FOR LACTIDE

The present invention relates to a method for producing lactide, which comprises the following steps: a first temperature rising and depressurization step for depressurization after raising a temperature of lactic acid up to 160-180anddeg;C; a second temperature rising and depressurization step for adding a reaction catalyst into a product obtained in the first temperature rising and depressurization step, raising the temperature up to 180-210anddeg;C at the rate of 1-10 anddeg;C/min, and depressurizing down to 0.001-1 torr at the rate of 5-20 torr/min; and a lactide extraction step for inserting the product obtained in the second temperature rising and depressurization step into a falling film reactor.COPYRIGHT KIPO 2017

PREPARATION METHOD FOR LACTIDE

The present invention refers to, after depressurization step at elevated temperature and elevated temperature until one of lactic acid 160 °C to 180 °C a pressures number 1; number 1 in the range from 1 °C/a pressures obtained resist reaction catalyst at elevated temperature and adding 210 °C temperature up to 180 °C 10 °C/min. after one rate, 20 torr/min. to about 5 torr/rate 0. 001 torr to 1 torr including number 2 to the depressurization step at elevated temperature and a pressures step; and said number 2 in water at elevated temperature and process of 0 °C to 40 °C a pressures obtained contact cleaning step; including a, number of bath method taken to lock are disclosed.

METHOD FOR MANUFACTURING LACTIDE

The invention pertains to a method for producing lactide comprising the steps of - providing a solution of lactic acid in a volatile organic solvent, - subjecting the solution to an evaporation step to remove volatile organic solvent and water, resulting in the formation of a composition comprising lactic acid oligomer, - adding catalyst to the composition comprising lactic acid oligomer, and bringing the mixture to reaction conditions, to form lactide. It has been found that the process according to the invention results in the efficient production of lactide with a high production rate and a good product quality.

Utilizing the catalytic synthesis mode of the method of preparing lactide

Utilizing the catalytic synthesis mode of the method of preparing lactide to a process for the preparation of lactide. The invention provides an environmental friendly, convenient operation by utilizing catalytic synthesis mode of the method of preparing lactide. Utilizing the catalytic synthesis mode of the method of preparing lactide, characterized in that comprises a lower step. Utilizing the catalytic synthesis mode of the method of preparing lactide, characterized in that comprises a lower step. (1) the D, L-lactic acid heating and dewatering. (2) lactic acid oligosynthetic oligomer. According to the quality than add a certain amount of catalyst, under reduced pressure (13.3KPa) re-under slow heating to 140 °C. (3) adding catalyst latter settles 10 minutes, stirring with water and again heated to 90 degree Celsius to maintain 3 to 5 hours after cooling. (4) low tetramer depolymerises ring. Replace the receiving device, re-started to rise quickly. (5) extraction separation: the resulting solution for 10 minutes later, extraction by adding extracting agent, after extraction to obtain solution, vested.

PREPARATION METHOD FOR LACTIDE

The lactic acid 160 °C to 180 °C a pressures after depressurization step at elevated temperature and elevated temperature until one number 1; and number 1 in the range from 1 °C/a pressures obtained resist reaction catalyst at elevated temperature and adding 10 °C/min. 180 °C to 210 °C temperature rate until after one, 20 torr/min. to about 5 torr/rate 0. 001 torr to 1 torr a pressures step including number 2 to the depressurization step at elevated temperature and; including a, number of bath method taken to lock are disclosed.

From meso-Lactide to Isotactic Polylactide: Epimerization by B/N Lewis Pairs and Kinetic Resolution by Organic Catalysts

B/N Lewis pairs have been discovered to catalyze rapid epimerization of meso-lactide (LA) or LA diastereomers quantitatively into rac-LA. The obtained rac-LA is kinetically polymerized into poly(l-lactide) and optically resolved d-LA, with a high stereoselectivity kL/kD of 53 and an ee of 91% at 50.6% monomer conversion, by newly designed bifunctional chiral catalyst 4 that incorporates three key elements (β-isocupreidine core, thiourea functionality, and chiral BINAM) into a single organic molecule. The epimerization and enantioselective polymerization can be coupled into a one-pot process for transforming meso-LA directly into poly(l-lactide) and d-LA.