109017-91-6

Upstream product

• 59167-68-9 4,5-dimethyl-3H-oxazol-2-one 
• 100-44-7 benzyl chloride 
• 6295-31-4 N-(Phenylmethyl)-2-hydroxypropanamide 
• 73818-55-0 Bestmann ylide 
• 513-86-0 3-hydroxy-2-butanon 
• 3173-56-6 benzyl isothiocyanate 
• 79658-55-2 3-benzyl-5-methyl-1,3-oxazolidine-2,4-dione 
• 75-16-1 methylmagnesium bromide 
• 124-38-9 carbon dioxide 
• 2028-63-9 but-3-yn-2-ol 
• 100-46-9 benzylamine 

Downstream Products

• 1424292-00-1 C₁₂H₁₅NO₃ 

Relevant academic research and scientific papers

Conversion of carbon dioxide into 2-oxazolidinones and 2(3H)-oxazolones catalyzed by 2,2′,2″-terpyridine

The catalytic activation of pyridines as organocatalysts in the three-component cycloaddition of CO2, propargyl alcohol and primary amine was investigated, and 2,2′,2″-Terpyridine was found to be the efficient organocatalyst to afford 4-methylene-2-oxazolidinones or 2(3H)-oxazolones in good to high yields. 2,2′,2″-Terpyridine also showed high catalytic activity in the coupling reaction of CO2 with aziridines bearing either electron-donating or electron-withdrawing N-substituents to give substituted 2-oxazolidinones in high yields.

Stereoselective addition of grignard reagents and lithium alkyls onto 3,5-disubstituted-1,3-oxazolidine-2,4-diones

3-Benzyl-5-methyl-1,3-oxazolidine-3,4-diones react with Grignard reactants and with lithium alkyls to yield 4-substituted 3-benzyl-4-hydroxy-5-methyl-1,3- oxazolidine-2-ones. The reaction is stereoselective and follows Cram's rule.

A single-step synthesis of 4-oxazolin-2-ones and their use in the construction of polycyclic structures bearing quaternary stereocenters

A new method for the synthesis of 4-oxazolin-2-ones by a one-pot MW-promoted condensation of a-ketols and isocyanates is reported. An alternative thermal approach using the same starting materials is also described. These cyclic enamides were efficient nucleophiles, reacting with Michael acceptors and prenyl bromide to give a variety of polycyclic structures bearing one or two quaternary stereocenters. The selectivity of the products depended on the reaction conditions and on the electrophile used. Wiley-VCH Verlag GmbH & Co. KGaA.

2(3H)-oxazolones from α-hydroxy amides and keteneylidenetriphenylphosphorane via a phoshorus ylide cascade

Upon heating in xylene α-hydroxyamides 3 react with the cumulated phosphorus ylide 1 to give the substituted 2(3H)-oxazolones 8 in 40-80% yield. The reaction proceeds via an addition/cyclization/intermolecular-Wittig olefination sequence, which implies th