6298-03-9

Basic information

• Product Name: H-LYS(ALLOC)-OH
• Synonyms: nδ-alloc-l-lysine;(S)-6-(((Allyloxy)carbonyl)aMino)-2-aMinohexanoic acid;NSC 45852;(2S)-2-Amino-6-[[(prop-2-en-1-yloxy)carbonyl]amino]hexanoic acid;N6-[(2-Propen-1-yloxy)carbonyl]-L-lysine;L-Lys(Aloc)-OH;Ne-Allyloxycarbonyl-L-lysine;(2S)-2-amino-6-(prop-2-enoxycarbonylamino)hexanoic acid
• CAS NO: 6298-03-9
• Molecular Formula: C₁₀H₁₈N₂O₄
• Molecular Weight: 230.26092
• Mol File: 6298-03-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 414.9°C at 760 mmHg
• Flash Point: 204.7°C
• Appearance: /
• Density: 1.153g/cm³
• Vapor Pressure: 4.8E-08mmHg at 25°C
• Refractive Index: 1.498
• Storage Temp.: Store at RT.
• PKA: 2.53±0.24(Predicted)
• CAS DataBase Reference: H-LYS(ALLOC)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-LYS(ALLOC)-OH(6298-03-9)
• EPA Substance Registry System: H-LYS(ALLOC)-OH(6298-03-9)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 6298-03-9(Hazardous Substances Data)

Usage

General Description

H-LYS(ALLOC)-OH is a chemical compound composed of H-LYS, which stands for N6-alloc-L-lysine, and OH, which stands for hydroxide. N6-alloc-L-lysine is a derivative of the amino acid L-lysine, which is commonly found in proteins and is essential for human health. The alloc group in N6-alloc-L-lysine is a protecting group commonly used in organic synthesis to prevent unwanted reactions at specific sites in the molecule. The addition of the hydroxide group to N6-alloc-L-lysine results in the formation of H-LYS(ALLOC)-OH, a potentially useful compound in chemical synthesis and drug development.

InChI:InChI=1/C10H18N2O4/c1-2-7-16-10(15)12-6-4-3-5-8(11)9(13)14/h2,8H,1,3-7,11H2,(H,12,15)(H,13,14)

Upstream product

• 104669-73-0 N^α-(tert-butoxycarbonyl)-N^ε-(allyloxycarbonyl)-L-lysine 
• 56-87-1 L-lysine 
• 2937-50-0 Allyl chloroformate 
• 372-75-8 Citrulline 

Downstream Products

• 159857-88-2 N-Cbz-Phe-Lys(ε-Alloc)OH 
• 1279111-08-8 Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-deacetylcolchicine 
• 1279111-09-9 Benzyloxycarbonyl-L-phenylalanyl-L-lysyl-PABC-4-fluorodeacetylcolchicine 
• 1279111-12-4 C₅₅H₆₀FN₅O₁₃ 
• 1279111-11-3 C₅₅H₆₁N₅O₁₃ 
• 71448-16-3 Cbz-L-Phe-L-Lys-OH 
• 159857-89-3 N-Cbz-Phe-Lys(ε-Alloc)-4-aminobenzyl alcohol 
• 159857-90-6 N-Cbz-Phe-Lys(ε-Alloc)-4-aminobenzyl 4-nitrophenyl carbonate 
• 1160844-44-9 C₃₈H₄₅N₅O₁₁ 
• 1160844-43-8 C₃₁H₄₂N₄O₇ 

Relevant articles and documents

PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF

This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.

PALLADIUM-CATALYZED REACTION OF TRIBUTYLTIN HYDRIDE. SELECTIVE AND VERY MILD DEPROTECTION OF ALLYL AND ALLYLOXYCARBONYL DERIVATIVES OF AMINO-ACIDS.

Allyl(All) and Allyloxycarbonyl(Alloc) amino-acid derivatives are deprotected through palladium-catalyzed hydrostannolysis by Bu3SnH in a highly selective manner.Benzyl and benzyloxycarbonyl groups are stable under these conditions.Moreover the allyl and Alloc groups seem orthogonal to the t-butyl and t-butoxycarbonyl protecting groups.