630-71-7

Usage

Physical state

White, crystalline solid

Odor

Faint

Usage

Fungicide and mildewcide in agriculture

Application

Used on a variety of crops, including fruits, vegetables, and ornamental plants

Mechanism of action

Inhibits the growth of fungal spores and prevents the spread of disease

Environmental concerns

Classified as a potential endocrine disruptor

Persistence

Has been linked to environmental concerns due to its persistence and potential for bioaccumulation

Regulation

Use is regulated in several countries to minimize environmental and human health risks

InChI:InChI=1/C14H9Cl2F3O/c15-11-5-1-9(2-6-11)13(20,14(17,18)19)10-3-7-12(16)8-4-10/h1-8,20H

Upstream product

• 379-18-0 1,1-diphenyl-2,2,2-trifluoroethanol 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 407-25-0 trifluoroacetic anhydride 
• 426-58-4 (trifluoromethylsulfonyl)benzene 
• 90-98-2 4,4'-Dichlorobenzophenone 
• 2708-87-4 diethoxytrifluoromethylphosphonate 
• 75-46-7 trifluoromethan 
• 321-37-9 4'-chloro-2,2,2-trifluoroacetophenone 
• 1679-18-1 4-Chlorophenylboronic acid 

Downstream Products

• 560-97-4 2.2.2-Trifluor-1-chlor-1.1-bis-(4-chlor-phenyl)-aethan 
• 1995-42-2 N-<1,1-Bis-(4-Chlor-phenyl)-2,2,2-trifluor-aethyl>-benzamid 
• 2247-71-4 N-<1,1-Bis-(4-chlor-phenyl)-2,2,2-trifluor-aethyl>-acetamid 
• 361-07-9 1,1,1-trifluoro-2,2-bis(p-chlorophenyl)ethane 
• 192826-39-4 toluene-4-sulfonic acid 1,1-bis-(4-chloro-phenyl)-2,2,2-trifluoro-ethyl ester 

Relevant academic research and scientific papers

METHOD FOR PRODUCING TRIFLUOROMETHYL GROUP-CONTAINING ALCOHOLS

PROBLEM TO BE SOLVED: To provide a method for producing CF3 group-containing alcohols useful as production intermediates for medicines and agrochemicals. SOLUTION: The method for producing CF3 group-containing alcohols represented by formula (2) comprises

Organocatalyzed Trifluoromethylation of Ketones and Sulfonyl Fluorides by Fluoroform under a Superbase System

Fluoroform (HCF3, HFC-23) is a side product in the manufacture of polytetrafluoroethylene (Teflon). Despite its attractive properties, taming HCF3 for trifluoromethylation is quite problematic owing to its low acidity and the labilit

A sterically demanding organo-superbase avoids decomposition of a naked trifluoromethyl carbanion directly generated from fluoroform

A simple strategy avoiding the decomposition of a naked trifluoromethyl anion to difluorocarbene by a sterically very demanding organo-superbase without the help of a trifluoromethyl anion reservoir such as DMF is reported. The direct non-metallic trifluoromethylation of carbonyl compounds using fluoroform in the presence of t-Bu-P4 base afforded trifluoromethyl alcohols in high yields.

Alkoxide-induced nucleophilic trifluoromethylation using diethyl trifluoromethylphosphonate

A novel alkoxide-induced nucleophilic trifluoromethylation of carbonyl compounds, disulfides, and diselenides using diethyl trifluoromethylphosphonate is presented. In these reactions diethyl trifluoromethylphosphonate acts as a [CF3-] synthon.

The rhodium-catalysed 1,2-addition of arylboronic acids to aldehydes and ketones with sulfonated S-Phos

The rhodium-catalysed 1,2-addition of arylboronic acids to aryl aldehydes has been accomplished in high yield using sulfonated S-Phos, a water-soluble biaryl phosphine ligand which allows for catalyst recycling. The catalytic protocol has also been successful in the challenging arylation of ketones.

Alkoxide- and hydroxide-induced nucleophilic trifluoromethylation using trifluoromethyl sulfone or sulfoxide

(Matrix presented) The first alkoxide- and hydroxide-induced nucleophilic trifluoromethylation of carbonyl compounds, disulfides, and other electrophiles, using phenyl trifluoromethyl sulfone 1a (sulfoxide 1b) is reported. The trifluoromethyl sulfone 1a or sulfoxide 1b acts as a CF3 - synthon. Both sulfone 1a and sulfoxide 1b are commercially available and can also be conveniently prepared from trifluoromethane. The new methodology provides a convenient route for efficient trifluoromethylation.

Substituent Effects on the Solvolysis of 1,1-Diphenyl-2,2,2-trifluoroethyl Tosylates: Comparison between Symmetrically Disubstituted and Monosubstituted Systems

The solvolysis rates of 1-(substituted phenyl)-1-phenyl-2,2,2-trifluoroethyl and 1,1-bis(substituted phenyl)-2,2,2-trifluoroethyl tosylates or bromides were conductimetrically measured at 25.0 °C in 80% aqueous ethanol. The substituent effects on these so