63002-95-9

Upstream product

• 18600-54-9 2-(4-methylphenyl)-4H-3,1-benzoxazin-4-one 
• 35709-65-0 2-(4-methylbenzoylamino)benzoylhydrazine 
• 52942-49-1 2-(4-tolyl)-4-oxo-4H-2,3-dihydro-1,3-benzoxazine 
• 253122-05-3 N-(4-methylbenzoyl)anthranilic acid 
• 118-92-3 anthranilic acid 
• 874-60-2 4-methyl-benzoyl chloride 

Downstream Products

• 18818-41-2 2-(4-methylphenyl)-4(3H)-quinazolinone 
• 174759-03-6 2-p-Tolyl-3-((3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-ylamino)-3H-quinazolin-4-one 
• 1228146-43-7 C₁₇H₁₄ClN₃O₂ 
• 1228146-47-1 C₂₄H₁₈N₆O₃S 
• 1228146-50-6 C₂₅H₁₉N₅O₃S 
• 1414886-83-1 3-{[(3-(pyridin-4-yl)-1-(p-tolyl)-1H-pyrazol-4-yl)methylene]amino}-2-(p-tolyl)quinazolin-4(3H)-one 

Relevant academic research and scientific papers

ANTI-ULCERATIVE COLITIS COMPOUND

Anti-ulcerative colitis compounds include quinazoline derivatives having the following structural formula: wherein R is H, OH, or OCH3, R1 is OH or OCH3, and R2 is OCH3, or a pharmaceutically acceptab

Design, synthesis and anticonvulsant evaluation of N-[(substituted 1H-pyrazol-3-yl)amino]-2-(4-methylphenyl)quinazolin-4(3H)-one derivatives

A series of quinazolinone derivatives (7a-7e) have been designed, synthesized and evaluated for the anticonvulsant activity using maximal electroshock seizure (MES) model. The compound 3-[(5-(4-chloro)phenyl-4,5-dihydro-1H-pyrazol-3-yl)amino]-2-(4-methylphenyl)quinazolin-4(3H)-one (7c) was found to be most active compound showing 85.23 % protection and was found to be nonneurotoxic up to 4 h. This study indicates that the quinazolinone based derivatives could be further exploited for the discovery of newer and more effective anticonvulsant agents.

Development of certain novel N-(2-(2-(2-oxoindolin-3-ylidene)hydrazinecarbonyl)phenyl)-benzamides and 3-(2-oxoindolin-3-ylideneamino)-2-substituted quinazolin-4(3 H)-ones as CFM-1 analogs: Design, synthesis, QSAR analysis and anticancer activity

The reaction of N-(2-(hydrazinecarbonyl)aryl)benzamides 2a, b with indoline-2,3-diones 4ae in acidified ethanolic solution furnished the corresponding N-(2-(2-(2-oxoindolin-3-ylidene)hydrazinecarbonyl)phenyl)benzamides 5aj, respectively. Furthermore, 3-(2

Design and synthesis of quinazolinone tagged acridones as cytotoxic agents and their effects on EGFR tyrosine kinase

In a quest for finding potent cytotoxic molecules, we have designed and synthesized a new scaffold by tagging quinazolinones with an acridone moiety. The new acridone-4-carboximide derivatives were evaluated for their cytotoxic potentials against the MCF7 breast cancer cell line and three colon cancer cell lines (LS174T, SW1398, and WiDr). Compound 26 showed relatively potent cytotoxic activity among the derivatives, against all the cell lines tested. Mechanistic studies for the selected derivatives 7, 8, 16, 17, 25, and 26 were conducted through in vitro EGFR tyrosine kinase inhibition studies. The results indicate that compound 26 has a better EGFR tyrosine kinase inhibitory profile. The in vitro EGFR inhibition data was correlated with the cytotoxic properties, and molecular docking studies were performed with regard to the receptor autophosphorylation sites of the protein kinase domain of the EGFR.

Synthesis and characterization of quinazoline derivatives: Search for hybrid molecule as diuretic and antihypertensive agents

To explore the pharmacological and structure-activity relationship of a series of N-substituted-(4-oxo-2-substituted-phenylquinazolin-3-(4H)-yl), substituted benzene sulfonamide derivatives (1-25) were synthesized from substituted anthranilic acids derive

Synthesis of some N-(4-oxo-2-sustitutedphenylquinazolin-3-(4H)-yl)-2-[(5- aryl-1,3.4-oxadiazol-2-yl) sulfanyl] acetamides as antitubercular agents

A series of some N-(4-oxo-2-substituted phenylquinazolin-3-(4H)-yl)-2-[(5- aryl-1,3,4-oxadiazol-2-yl) sulfanyl] acetamides 5 were synthesized and characterized on the basis of IR, NMR and mass spectral data. The title compounds were subjected to in-vitro

Reaction of 2-Aryl-3,1-benzoxazine-4-ones with Hydrazine Hydrate: A Reinvestigation

The reaction of 2-aryl-3,1-benzoxazine-4-ones (I) and hydrazine hydrate in refluxing xylene yields 2-aryl-3-aminoquinazolin-4(3H)-ones (III), instead of 2-aryl-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones (II).III is also obtained by treating I with hydrazi

A New Synthesis of 2-Aryl-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones

The reaction of 2-aryl-3,1-benzoxazine-4-ones (1) and hydrazine hydrate in refluxing xylene yields 2-aryl-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones in 55-74percent yield.In basic conditions this reaction, however, gives 2-aryl-3-aminoquinazolin-4(3H)-one