63007-54-5

Upstream product

• 64-18-6 formic acid 
• 873-38-1 4-chloro-2-bromoaniline 
• 141-53-7 sodium formate 

Downstream Products

• 1258545-95-7 1-bromo-5-chloro-2-isocyanobenzene 
• 92104-30-8 6-chloro-3-phenylquinazolin-4(3H)-one 
• 1536478-61-1 (E)-N-[4-chloro-2-(prop-1-enyl)phenyl]formamide 
• 19358-40-8 6-chloro-1,2,3,4-tetrahydroquinolin-2-one 
• 90537-20-5 5-chloro-3-methyl-2-indolinone 
• 1536478-45-1 N-(4-chloro-2-vinylphenyl)formamide 

Relevant academic research and scientific papers

Furo-pyridone imidazole compound as well as preparation method and application thereof

The invention belongs to the field of medicinal chemistry. Specifically, the invention relates to a furo-pyridone imidazole compound as well as a preparation method and application thereof. The structure of the compound is shown as a general formula (I). The compounds or the stereoisomers, racemes, geometric isomers, tautomers, prodrugs, hydrates, solvates or pharmaceutically acceptable salts and pharmaceutical compositions thereof can be used for treating or/and preventing related diseases mediated by the FXIa (Factor XIa for short).

Furo-pyridone amide compound as well as preparation method and application thereof

The invention belongs to the field of medicinal chemistry. The invention relates to a furo-pyridone amide compound as well as a preparation method and application thereof. Specifically, the structure of the compound is shown as a general formula (I) in th

Alkoxy pyridone compound as well as preparation method and application thereof

The invention belongs to the field of medicinal chemistry, specifically, the invention relates to a series of inhibitors of factor XIa (FXIa for short) with a novel structure as well as a preparationmethod and an application thereof. The structure is shown as the following general formula (I). These compounds or stereoisomers, racemates, geometric isomers, tautomers, prodrugs, hydrates, solvatesor pharmaceutically acceptable salts and pharmaceutical compositions thereof can be used to treat or/and prevent related diseases mediated by factor XIa (FXIa for short).

One-pot synthesis of 1,4-dihydro-3,1-benzoxazine-2-thiones by the reaction of 2-lithiophenyl isothiocyanates with aldehydes or ketones

An efficient one-pot method for the synthesis of 4-monosubstituted and 4,4-disubstituted 1,4-dihydro-3,1-benzoxazine-2-thiones has been developed. Treatment of 2-bromophenyl isothiocyantes with butyllithium in THF at -78 °C generates 2-lithiophenyl isothi