19358-40-8

Basic information

• Product Name: 6-CHLORO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE
• Synonyms: 6-CHLORO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE;6-Chloro-3,4-dihydroquinolin-2(1H)-one;6-Chloro-1,2,3,4-tetrahydroquinolin-2-one
• CAS NO: 19358-40-8
• Molecular Formula: C₉H₈ClNO
• Molecular Weight: 181.61892
• Mol File: 19358-40-8.mol
• Article Data: 21

Chemical Properties

• Melting Point: 106 °C
• Boiling Point: 362.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.290±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.86±0.20(Predicted)
• CAS DataBase Reference: 6-CHLORO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE(19358-40-8)
• EPA Substance Registry System: 6-CHLORO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE(19358-40-8)

Safety Data

• Hazardous Substances Data: 19358-40-8(Hazardous Substances Data)

Usage

General Description

6-CHLORO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE is a chemical compound that belongs to the class of quinolone antibiotics. It is a derivative of 1H-quinolin-2-one with a chlorine atom at the 6 position and a 3,4-dihydro substitution. 6-CHLORO-3,4-DIHYDRO-1H-QUINOLIN-2-ONE is known for its antibacterial and antifungal properties and is used in the synthesis of various pharmaceuticals. It has also been studied for its potential therapeutic applications in the treatment of bacterial and fungal infections. Additionally, it has been investigated for its potential use as an anti-inflammatory agent.

Upstream product

• 553-03-7 3,4-dihydro-2(1H)-quinolone 
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• 63007-54-5 N-(2-bromo-4-chlorophenyl)formamide 
• 49716-18-9 6-chloro-1,2,3,4-tetrahydroquinoline 
• 52085-96-8 3-(4-chlorophenyl)propanoyl chloride 
• 2019-34-3 3-(4-chlorophenyl)propanoic acid 
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• 140-88-5 ethyl acrylate 
• 106-47-8 4-chloro-aniline 
• 457622-18-3 3-(2-amino-5-chlorophenyl)-1-propanol 
• 7446-70-0 aluminium trichloride 
• 19314-16-0 3-chloro-N-(4-chlorophenyl)propanamide 

Downstream Products

• 2126744-35-0 4-((6-chloro-3,4-dihydroquinolin-1(2H)-yl)methyl)-N-hydroxybenzamide 
• 78060-46-5 6-chloro-2-piperazin-1-yl-quinoline 
• 871269-47-5 (Z)-3-(1-acetylamino-1-phenylmethylene)-6-chloro-1-methyl-3,4-dihydroquinolin-2(1H)-one 
• 1810-72-6 2,6-dichloroquinoline 

Relevant articles and documents

Dehydrogenative and Redox-Neutral N-Heterocyclization of Aminoalcohols Catalyzed by Manganese Pincer Complexes

A new manganese catalyzed heterocyclization of aminoalcohols has been accomplished. A wide range of heterocycles were synthesized, including 1,2,3,4-tetrahydroquinolines, dihydroquinolinones, and 2,3,4,5-tetrahydro-1H-benzo[b]azepines. The reaction is performed under mild reaction conditions using air and moisture stable manganese catalysts. The desired heterocycles were obtained in good to excellent yields.

Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model

Histone deacetylase 6 (HDAC6) is a promising therapeutic target for the treatment of neurodegenerative disorders. SW-100 (1a), a phenylhydroxamate-based HDAC6 inhibitor (HDAC6i) bearing a tetrahydroquinoline (THQ) capping group, is a highly potent and sel

METHOD FOR PRODUCING LACTAM COMPOUND, AND LACTAM COMPOUND PRODUCED THEREBY

The present invention relates to a method for producing a lactam compound from dioxazolone in the presence of a catalyst having a particular ligand, and to a lactam compound produced thereby, and can produce a lactam compound with excellent selectivity and an excellent yield by using the combination of a starting material having a particular functional group and a particular catalyst having a particular ligand.