97892-66-5

Usage

Uses

Used in Pharmaceutical Research and Development:
7-Chloro-4-hydrazino-2-methylquinoline is used as a compound with potential biological activities for the development of new pharmaceuticals. Its antimicrobial, antitumor, and antiviral properties make it a promising candidate for treating various diseases.
Used in Organic Synthesis:
7-CHLORO-4-HYDRAZINO-2-METHYLQUINOLINE is also used as a versatile building block in the synthesis of other organic compounds, contributing to the creation of new chemical entities with potential applications in various fields.

InChI:InChI=1/C10H10ClN3/c1-6-4-10(14-12)8-3-2-7(11)5-9(8)13-6/h2-5H,12H2,1H3,(H,13,14)

Upstream product

• 50593-69-6 4,7-dichloro-2-methylquinoline 
• 15644-88-9 7-chloro-4-hydroxy-2-methylquinoline 
• 63010-73-1 ethyl β-(3-chloroanilino)crotonate 
• 108-42-9 3-chloro-aniline 

Downstream Products

• 68017-47-0 7-chloro-4-amino-2-methylquinoline 

Relevant academic research and scientific papers

N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors

A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.

Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives

Nickel(II) chloride/sodium borohydride combination was employed for the reduction of 4-hydrazinoquinoline derivatives to the corresponding anilines. This reductive protocol was efficiently applied for the reductive cleavage of monosubstituted hydrazines. We described herein the microwave-assisted synthesis of 4-hydrazinoquinolines, which furnished a high yielding and rapid two-step procedure for the synthesis, under mild conditions, of 4-aminoquinolines as antimalarial precursors.