63012-90-8Relevant academic research and scientific papers
A new class of potent hypolipemic agents raising high-density lipoproteins. Synthesis, reactions and pharmacological properties
Furrer, H.,Granzer, E.,Wagner, R.
, p. 819 - 830 (1994)
A series of thiazolopyrimidin-5,7-diones has been synthesized.Results from in vivo evaluations in rats have shown that many of these compounds produce a pronounced increase of HDL cholesterol and a marked decrease of LDL and VLDL cholesterol.The mo
New Heterocyclic Structures. Thiazinopurine and Triazolothiazinopyrimidine
Pecorari, Piergiorgio,Rinaldi, Marcella,Costi, Maria Paola
, p. 1701 - 1705 (2007/10/02)
Derivatives of two new molecular structures, namely, thiazinopurine and triazolothiazinopyrimidine, were synthesized together with other heterocyclic compounds.Retrosynthetic analysis of their molecular skeletons suggested a simple way of obtaining 3,4-dihydro-7,8-diamino-2H,6H-pyrimidothiazin-6-one, which is a useful intermediate for their synthesis.This intermediate and the thiazole homologue were obtained directly by reaction of 5,6-diamino-2,3-dihydro-2-thioxo-4(1H)-pyrimidinone with 1,3- or 1,2-dibromoalkane, respectively.
