6304-18-3

Usage

Uses

Used in Food and Beverage Industry:
3-propan-2-ylpyridine is used as a flavoring agent for its unique taste and aroma, enhancing the sensory experience of various food and drink products.
Used in Perfumes and Cosmetics:
3-propan-2-ylpyridine is used as a fragrance component in perfumes and cosmetics, adding a distinct scent to these products and contributing to their overall appeal.
Used in Pharmaceutical Applications:
3-propan-2-ylpyridine is studied for its potential use as an insect repellent, providing a natural alternative to chemical-based repellents and offering protection against insect-borne diseases.
Used in Organic Synthesis:
3-propan-2-ylpyridine serves as a building block for the synthesis of other organic compounds, enabling the creation of new molecules with various applications in different industries.

Upstream product

• 108-99-6 3-Methylpyridine 
• 74-87-3 methylene chloride 
• 7664-41-7 ammonia 
• 626-55-1 3-Bromopyridine 
• 1239384-16-7 [2-(2-hydroxyprop-2-yl)phenyl]triisopropylsilane 
• 626-60-8 3-Chloropyridine 
• 1068-55-9 isopropylmagnesium chloride 
• 54-36-4 metyrapone 
• 78156-25-9 3-i.propyl-5,5-diethoxypentanal 

Downstream Products

• 38031-78-6 3-tert-butylpyridine 
• 1379583-49-9 N-benzyl-3-isopropylpyridinium bromide 
• 70451-68-2 1-methyl-3-(1-methylethyl)-2(1H)-pyridone 
• 70451-69-3 1-methyl-5-(1-methylethyl)-2(1H)-pyridone 

Relevant academic research and scientific papers

Iron-Catalyzed Isopropylation of Electron-Deficient Aryl and Heteroaryl Chlorides

Traditional methods for the preparation of secondary alkyl-substituted aryl and heteroaryl chlorides challenge both selectivity and functional group tolerance. This contribution describes the use of statistical design of experiments to develop an effective procedure for the preparation of isopropyl-substituted (hetero)arenes with minimal isopropyl to n-propyl isomerization. The reaction tolerates electronically diverse aryl chloride coupling partners, with excellent conversion observed for strongly electron-deficient aromatic rings, such as esters and amides. Electron-rich systems, including methyl- and methoxy-substituted aryl chlorides, were found to be less reactive. Furthermore, the reaction was found to be most successful when heteroaryl chlorides were submitted to the cross-coupling protocol. By mapping substituent effects on reaction selectivity, we were able to show that electron-deficient aryl chlorides are essential for efficient coupling, and use electronic structure calculations to predict the likelihood of successful coupling through the estimation of the electron affinity of each aryl chloride. Moderate isolated yields were achieved with selected aryl chlorides, and moderate to good isolated yields were obtained for all the heteroaryl chlorides coupled. Excellent selectivity was observed when a 2,6-dichloroquinoline was used, allowing mono-substitution on a challenging substrate. (Figure presented.).

Cross-coupling reactions through the intramolecular activation of Alkyl(triorgano)silanes

(Figure Presented) Cross-Si-ing the Jordan: Cross-coupling reactions of 2-(2-hydroxyprop-2-yl)phenylsubstituted alkylsilanes with a variety of aryl halides proceed in the presence of palladium and copper catalysts. The use of K3PO4 base allows for highly chemoselective alkyl coupling with both primary and secondary alkyl groups (Alk).

The photochemistry of metyrapone

Metyrapone undergoes efficient α-cleavage via the n0?* triplet.The fate of the resulting acyl and alkyl radicals has been determined by transient studies as well as through the isolation of the final products, quantum yield measurements and trapping studies.Processes previously documented for carbocyclic analogues of 1, such as disproportionation and coupling of the alkyl radicals and recombination to the starting compound are here accompanied by another major process, viz. coupling with attack of the acyl radical on the pyridine ring, which eventually leads mainly to a polymeric material.