6304-98-9

Upstream product

• 51127-13-0 2-phenyl-4-methyl-4H-oxazolin-5-one 
• 2198-64-3 N-Benzoylalanine 
• 5446-46-8 ethyl 2-(benzoylamino)propanoate 
• 62-53-3 aniline 
• 90-02-8 salicylaldehyde 
• 103-72-0 phenyl isothiocyanate 
• 555-48-6 2-amino-N-phenyl-acetamide 
• 2198-64-3 N-benzoyl-L-alanine 
• 101961-58-4 2-amino-N-phenylpropanamide 
• 65-85-0 benzoic acid 
• 78993-81-4 4-(1-Anilino-1-phenylmethyl)-4-methyl-2-phenyl-2-oxazolin-5-one 
• 397851-05-7 N-Benzoylalanyl chloride 
• 98-88-4 benzoyl chloride 
• 126727-23-9 <1-(N-tert-butyloxycarbonyl)amino-1-methyl>-N-phenylacetamide 

Downstream Products

• 6304-98-9 (S)-N-benzoyl-alanine anilide 
• 56-41-7 L-alanin 

Relevant academic research and scientific papers

A study of the strength of a template molecule - A functional monomer interaction that affects the performance of molecularly imprinted polymers and its application to chiral amplification

A novel type of molecularly imprinted polymer (MIP), N-benzoyl-(S)-valine anilide-imprinted polymer (IP-2), was prepared using hydrogen-bonding interactions as a main force in the pre-polymerization step. The performance of the IP-2 was evaluated via batch procedure and compared with a (S)-valine anilideimprinted polymer (IP-1) that was prepared using an ionic interaction that is stronger than hydrogen bonding. Although both polymers showed a preferential adsorbability for (S)-amino acid derivatives, different performances were observed in terms of adsorbability and enantioselectivity. In addition, the IP-2 was able to recognize the enantiomer of a valine-derived chiral catalyst. This phenomenon was applied to a chiral amplification reaction, and a highly selective asymmetric Mannich-type amination was achieved using the combination of a racemic catalyst and a MIP.

Br?nsted acid catalyzed azlactone ring opening by nucleophiles

Br?nsted acid catalyzed azlactone ring opening in the presence of different nucleophiles leading to the efficient synthesis of protected amides and amino esters is presented. Sixteen compounds were synthesized in good to excellent isolated yields. Mechani

Remarkable shape-sustaining, load-bearing, and self-healing properties displayed by a supramolecular gel derived from a bis-pyridyl-bis-amide of L -phenyl alanine

A series of bis-amides decorated with pyridyl and phenyl moieties derived from L-amino acids having an innocent side chain (L-alanine and L-phenyl alanine) were synthesized as potential low-molecular-weight gelators (LMWGs). Both protic and aprotic solven

Synthesis and anticonvulsant activity of some 2/3- benzoylaminopropionanilide derivatives

In this study, the synthesis and anticonvulsant properties of sixteen 2/3-benzoylaminopropionanilide derivatives were described. Molecular design of the compounds has been based on the modification of lacosamide which is a functionalized amino acid with a novel anticonvulsant activity. The structural confirmation of the title compounds was achieved by spectral and analytical data. The anticonvulsant activity profile of synthesized compounds was determined by maximal electroshock (MES) and subcutaneous metrazole (scMet) seizure tests, whereas their neurotoxicity was examined using rotarod test. All these tests were performed in accordance with the procedures of the Antiepileptic Drug Development (ADD) program. The majority of the compounds were effective in the MES or scMet screening tests. None of the compounds showed neurotoxicity according to the rotarod test at studied doses. Most active compounds in the series were 3, 12 and 13, which bearing 2-methyl, 2-ethyl and 2-isopropyl substituent on the N-phenyl ring, respectively. Georg Thieme Verlag KG Stuttgart - New York.

Aminothiazole derivative. I. A convenient synthesis of monocyclic and condensed 5-aminothiazole derivatives

Treatment of diamides derived from α-amino acids with phosphorus pentasulfide or Lawesson's reagent was shown to provide a convenient method to prepare 5-aminothiazoles. By this method, in addition to monocyclic 5-aminothiazoles 19, novel bicyclic 5-aminothiazole derivatives such as 4,5,6,7-tetrahydrothiazolo[5,4-b]pyridines II, 5,6,7,8-tetrahydro-4H-thiazolo[5,4-b]azepines 7, 4,5,6,7,8,9-hexahydrothiazolo[5,4-b]azocine 16 and related compounds were prepared in moderate to good yields from simple diamides, suggesting the wide versatility of the method.

Isothiocyanate-Mediated Condensation of N-Acyl-α-amino Acids with Aromatic Aldehydes: One-Pot Synthesis of 1,2-Disubstituted 4-Arylmethylene-2-imidazolin-5-ones

N-Acetyl/benzoyl-amino acids (1c/1b, d) when heated with isothiocyanates (2) in the presence of suitable aromatic aldehydes (3) with pyridine as a catalyst, afford 1, 2-disubstituted 4-arylmethylene-2-imidazolin-5-ones (6).However, N-benzyloxycarbonylaminoacetic acid (1a) gives the corresponding anilide (11a).Mechanisms of these reactions are discussed.

Reaction of Phenyl Isothiocyanate with Some α,N-Acylamino and Dicarboxylic Acids

Dianilides are obtained in the reaction of phenyl isothiocyanate with dicarboxylic acids, such as oxalic, malonic, glutaric and adipic acids, and not in the case of succinic and phthalic acids.In the case of succinic acid, the product is monoanilide, dianilide or N-phenylsuccinimide, depending upon the reaction conditions.Phthalic acid always gives N-phenylphthalimide.N-Acylamino acids on reaction with phenyl isothiocyanate yield the corresponding anilides.The probable mechanisms of this reaction are discussed.

Reactions of 2-Phenyl-2-oxazolin-5-ones with Imines and Their Corresponding Carbonyl Compounds

The addition of 2-phenyl-2-oxazolin-5-ones (3) to benzylideneaniline, salicylideneaniline, benzaldehyde or salicylaldehyde affords different products depending upon the nature of the reactants.