6305-31-3

Usage

Chemical structure

1-(4-methylbenzyl)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylurea is a chemical compound with a complex ring structure and a urea functional group.

Derivation

It is derived from tricyclo[3.3.1.1~3,7~]decane, a bicyclic hydrocarbon with a bridged ring system.

4-methylbenzyl group

The presence of the 4-methylbenzyl group contributes to its aromatic and hydrophobic properties.

Urea functional group

Ureas are known for their diverse range of applications in organic synthesis, pharmaceuticals, and agrochemicals.

Specific properties

The specific properties and potential uses of 1-(4-methylbenzyl)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylurea would depend on its individual chemical and physical characteristics.

Further investigation

Further investigation and characterization would be needed to determine the specific properties and potential uses of 1-(4-methylbenzyl)-3-tricyclo[3.3.1.1~3,7~]dec-1-ylurea.

Upstream product

• 120-75-2 2-Methylbenzothiazole 
• 100-44-7 benzyl chloride 
• 1483-30-3 2-styrylbenzothiazole 
• 104-53-0 3-phenyl-propionaldehyde 
• 609-73-4 o-nitroiodobenzene 
• 100-42-5 styrene 
• 95-16-9 1,3-Benzothiazole 
• 100-51-6 benzyl alcohol 
• 2046-33-5 3-methoxypropylbenzene 
• 62-53-3 aniline 
• 14371-10-9 (E)-3-phenylpropenal 
• 137-07-5 2-amino-benzenethiol 
• 645-59-0 dihydrocinnamonitrile 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 95-16-9 1,3-Benzothiazole 
• 1629-78-3 2-acetylbenzothiazole 
• 35491-37-3 2-(benzo[d]thiazol-2-yl)-1-phenylethan-1-ol 

Relevant academic research and scientific papers

ZnO-NPs catalyzed condensation of 2-aminothiophenol and aryl/alkyl nitriles: Efficient green synthesis of 2-substituted benzothiazoles

The synthesis of 2-substituted benzothiazoles has been described using ZnO-nanoparticles as a catalyst. The condensation of 2-aminothiophenol and aryl/alkyl nitriles resulted in the formation of various 2-substituted benzothiazoles under solvent-free reaction conditions. The library of 2-substituted benzothiazoles has been synthesized in good to excellent yield. The reaction has shown a wide range of functional group compatibility for both varyingly substituted 2-aminothiophenols and nitriles. The protocol has many advantages such as faster reaction rate, mild reaction conditions, various functional group compatibility, excellent yield, solvent-free reaction conditions, easy recovery of materials, and excellent catalyst recyclability, among others. The various advantages of this protocol make it a more feasible, economical, and environmentally benign process.

Insertion Reaction of 2-Halo- N -allylanilines with K 2S Involving Trisulfur Radical Anion: Synthesis of Benzothiazole Derivatives under Transition-Metal-Free Conditions

A synthesis of benzothiazole derivatives through the reaction of 2-halo- N -allylanilines with K 2S in DMF is developed. The trisulfur radical anion S 3· -, which is generated in situ from K 2S in DMF, initiates

Ultrasound-assisted efficient and green synthesis of 2-substituted benzothiazoles under solvent-free condition using recyclable sulfated tungstate

Sulfated tungstate catalyzed an efficient and ecofriendly protocol has been described for the synthesis of 2-substituted benzothiazoles. The corresponding benzothiazoles were obtained using a condensation reaction of 2-aminothiophenol with various aldehydes under ultrasound irradiation at room temperature. Various functional groups on the 2-aminothiophenol as well as on the aldehydes were tolerated to provide 2-substituted benzothiazoles derivatives in excellent yields. The faster reaction rate, solvent-free or mild reaction conditions, wide functional group compatibility, excellent yields, easy work-up procedure, and excellent catalyst recyclability are the advantages of this protocol. These advantages make this process more practicable, cost-effective, and environmentally benign.

AcOH-mediated aerobic oxidative synthesis of 2-thioalkylbenzothiazoles via a three-component reaction

An AcOH-mediated three-component reaction of 2-aminothiophenols, α,β-unsaturated aldehydes, and thiophenols to prepare the high value-added 2-thioalkylbenzothiazoles was developed. The reaction was conducted under metal-free conditions, where oxygen served as the terminal oxidant. In addition, this strategy is tolerant of kinds of functional groups, providing efficient access to a variety of functionalized benzothiazole derivatives in moderate to good yields. What's more, this reaction has complete regioslectivity and provides a powerful method for building complex molecules.

TBHP/KI-Promoted Annulation of Anilines, Ethers, and Elemental Sulfur: Access to 2-Aryl-, 2-Heteroaryl-, or 2-Alkyl-Substituted Benzothiazoles

An efficient TBHP/KI-promoted annulation of anilines with ethers and elemental sulfur has been developed through the selective C-O bond cleavage of ethers under transition-metal-free conditions. A wide range of 2-aryl-, 2-heteroaryl-, and 2-alkyl-substituted benzothiazoles were easily prepared with satisfactory yields and good functional group compatibility.

N-Heterocyclic Carbene Ligand-Controlled Regioselectivity for Nickel-Catalyzed Hydroarylation of Vinylarenes with Benzothiazoles

A facile regioselective switch for nickel-catalyzed hydroarylation of vinylarenes with benzothiazoles has been developed, which relies on the simple structural variation of novel Ni(II) complexes of the type Ni(NHC)[P(OR)3]Br2. Using magnesium turnings as the reductant, Ni(IMes)[P(OEt)3]Br2 afforded branched products, while Ni(IPr?OMe)[P(OEt)3]Br2 created steric demand to afford linear products. This work also provides a rare example of the rational design of heteroleptic Ni(II) complexes that display the required air stability, reactivity, and regioselectivity via synergism between NHC and phosphite ligands.

A heterocyclic methyl compound dehydration C - alkylation method

The invention discloses a dehydration C-alkylation method for a heterocyclic methyl compound. According to the method, alcohol is used as an alkylation reagent and undergoes dehydration C-alkylation with the heterocyclic methyl compound without presence of a catalyst so as to synthesize an alkylated heterocyclic compound; meanwhile, alcohol and the heterocyclic methyl compound can be directly subjected to dehydration C-methyl alkylation reaction at methyl position in the presence of air and alkali, wherein the reaction temperature is 100 to 180 DEG C; the reaction time is 6 to 60 hours; the reaction solvent is an organic solvent; and a byproduct is water. According to the method, cheap, easily and widely available and stable alcohol with low toxicity is used as the alkylation agent; no catalyst is used; and the alkylated compound is directly synthesized via the dehydration C-alkylation reaction in the presence of air and alkali. The method provided by the invention has low demand for reaction conditions, a wide application range and certain research and industrial application prospects.

Method for synthesizing 1,2-bibenzyl compound

The invention discloses a method for synthesizing a 1,2-bibenzyl compound. According to the method, a nickelous (II) complex with the molecular formula being Ni[P(OEt)3][(RNCHCHNR)C]Br2 serves as a catalyst, wherein R is 2,6-diphenyl methyl-4-methoxyphenyl), and in the presence of metal magnesium, the 1,2-bibenzyl compound is synthesized through a cross-coupling reaction of benzo-(hetero)arene anda styrene compound. According to the method, the nickelous (II) complex with air stability serves as the catalyst for the first time, so that direct use of sensitive and dangerous metal compounds andzero-valent nickel (0) complexes is avoided; under mild reaction conditions, a zero-valent nickel (0) active center is formed in situ through the action of the metal magnesium, so that the cross-coupling reaction between the benzo-(hetero)arene and the styrene compound is achieved, and a novel method is provide for synthesis of the 1,2-bibenzyl compound.

Iron-catalyzed C-H alkylation of heterocyclic C-H bonds

An efficient, iron-catalyzed C-H alkylation of benzothiazoles by using alkyl diacyl peroxides and alkyl tertbutyl peresters which are readily accessible from carboxylic acids to synthesize 2-alkylbenzothiazoles is developed. This reaction is environmentally benign and compatible with a broad range of functional groups. Various primary, secondary, and tertiary alkyl groups can be efficiently incorporated into diverse benzothiazoles. The effectiveness of this method is illustrated by late-stage functionalization of biologically active heterocycles.

Visible-light-promoted synthesis of benzothiazoles from 2-aminothiophenols and aldehydes

A visible-light-promoted synthesis of benzothiazoles from 2-aminothiophenols and aldehydes has been developed. A wide range of aromatic, heteroaromatic and aliphatic aldehydes were successfully applied. The benzothiazole products were prepared in good yields. The reaction was carried out in the absence of transition-metal catalysts and extra additives. A radical reaction pathway was proposed.