1483-30-3Relevant articles and documents
Pentafluorophenylammonium Triflate: A Mild, Efficient and Reusable Catalyst for the Synthesis of 2-Arylbenzothiazole and 2-Arylbenzothiazoline Derivatives in a Green Chemical Approach
Datta, Arup
, p. 95 - 102 (2021/03/29)
In this work, one pot, simple and environmentally benign effective synthesis of 2-substituted benzothiazole and benzothiazoline derivatives are described in presence of PFPAT (pentafluorophenylammonium triflate) catalyst in water successfully. A series of benzothiazole derivative were synthesized by the reaction between 2-aminothiophenol and various aldehydes in good yields. Recyclability of the catalyst is observed for four times without loss of its activity in aqueous medium.
Synthesis of some benzothiazoles by developing a new protocol using urea nitrate as a catalyst and their antimicrobial activities
Kumar, Parvin,Bhatia, Rimpy,Khanna, Radhika,Dalal, Aarti,Kumar, Dinesh,Surain, Parveen,Kamboj, Ramesh C.
, p. 585 - 596 (2017/10/05)
The present communication demonstrates the development of urea nitrate as an effective and efficient catalyst for the synthesis of some 2-substituted benzothiazoles. Instant progress of reaction at room temperature under solvent-free condition, very high catalytic activity, inexpensive, clean reaction profile, operational simplicity, large-scale synthesis and appreciable yields are the main advantages of this protocol. These synthesized benzothiazoles have been evaluated for their antibacterial and antifungal activities against Gram-positive bacterium (Bacillus subtilis MTCC 121); two Gram-negative bacteria (Escherichia coli MTCC 1652 and Pseudomonas aeruginosa MTCC 741) and two fungi (Candida albicans MTCC 3017 and Saccharomyces cerevisiae MTCC 170). Compound 3n was found the most active against all the tested microbes.
Unexpectedly Simple Synthesis of Benzazoles by tBuONa-Catalyzed Direct Aerobic Oxidative Cyclocondensation of o-Thio/Hydroxy/Aminoanilines with Alcohols under Air
Shi, Xinkang,Guo, Junmei,Liu, Jianping,Ye, Mingde,Xu, Qing
supporting information, p. 9988 - 9993 (2015/07/07)
tBuONa-catalyzed direct aerobic oxidative cyclocondensation reactions of readily available alcohols and o-thio/hydroxy/aminoanilines under air have been developed and provide an efficient, practical, and green method for the synthesis of benzazoles. Mechanistic studies revealed that o-substituted anilines promote the initial aerobic alcohol-oxidation step, which explains the high reactivity and success of this unexpectedly simple and practical cyclocondensation method. Simple and straight: tBuONa-catalyzed direct aerobic oxidative cyclocondensation reactions of readily available alcohols and o-thio/hydroxy/aminoanilines under air provide an efficient, practical, and green method for the synthesis of benzazole heterocycles (see scheme). Mechanistic studies revealed that o-substituted anilines promote the initial aerobic alcohol-oxidation step.