6317-76-6

Usage

InChI:InChI=1/C19H13NO3/c21-19(17-10-12-18(13-11-17)20(22)23)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-13H

Upstream product

• 14062-23-8 4-biphenylylacetic acid ethyl ester 
• 98-95-3 nitrobenzene 
• 555-16-8 4-nitrobenzaldehdye 
• 1250286-28-2 C₁₉H₁₅NO₃ 
• 92-52-4 biphenyl 
• 62-23-7 4-nitro-benzoic acid 
• 122-04-3 4-nitro-benzoyl chloride 

Downstream Products

• 71969-47-6 (4-aminophenyl)biphenyl-4-ylmethanone 

Relevant academic research and scientific papers

Transition-Metal-Free Regiospecific Aroylation of Nitroarenes Using Ethyl Arylacetates at Room Temperature

A novel regiospecific C(sp3)-C(sp2) coupling between ethyl arylacetates and nitroarenes has been developed to deliver biaryl ketones in excellent yields. The protocol is metal-free, mild, and compatible with a number of functional groups on both of the reacting partners.

Tandem nucleophilic addition-Oppenauer oxidation of aromatic aldehydes to aryl ketones with triorganoaluminium reagents

In the presence of pinacolone, the in situ prepared triorganoaluminium reagents reacted with aromatic aldehydes to give ketones in moderate to high yield. We propose that the products are formed via a tandem organoaluminium reagents addition-Oppenauer oxidation sequence. The Royal Society of Chemistry 2013.

Metal-free oxidation of alcohols to their corresponding carbonyl compounds using NH4NO3/Silica sulfuric acid

A metal-free and efficient procedure for the oxidation of alcohols into the corresponding carbonyl compounds has been described using ammonium nitrate in the presence of silica sulfuric acid under mild and heterogeneous conditions. The use of non-toxic and inexpensive materials, simple and clean work-up, short reaction times and good yields of the products are among the advantages of this method.

Simple and efficient procedure for the friedel-crafts acylation of aromatic compounds with carboxylic acids in the presence of P2O5/AL2O3 under heterogeneous conditions

An efficient and chemoselective method for the Friedel-Crafts acylation of aromatic compounds using P2O5/Al2O3 and carboxylic acids. Both aromatic and aliphatic carboxylic acids reacted easily to afford the corresponding aromatic ketones in good yields.

Friedel-Crafts acylation of aromatic compounds with carboxylic acids in the presence of P2O5/SiO2 under heterogeneous conditions

A convenient and efficient procedure for the Friedel-Crafts acylation of aromatic compounds with carboxylic acids in the presence of P2O5/SiO2 is described. Both aromatic and aliphatic carboxylic acids reacted easily to afford the corresponding aromatic ketones. The use of non-toxic and inexpensive materials, simple and clean work-up, short reaction times and good yields of the products are the advantages of this method.

Synthesis of arylketones using Envirocat EPZG catalyst

The Friedel-Crafts acylation reactions of substituted benzene derivatives with substituted acid chlorides proceed smoothly in the presence of a catalytic amount of Envirocat EPZG, a novel supported reagent catalyst, based on montmorillonite K10 clay. This catalyst is eco-friendly, selective and reusable and hence provides a safer and a cost effective approach for large-scale production in industries. The present work involves synthesis of fifteen ketones by using fresh and reused Envirocat EPZG catalyst and a conventional catalyst for Friedel-Crafts reaction, anhyd. AlCl3. The yields of ketones with fresh Envirocat EPZG are always more than that obtained with anhyd. AlCl3. Envirocat EPZG has been reused for the number of reactions in a series, without much loss in its efficiency. Ketones having activating as well as deactivating groups on benzene ring have been synthesized in satisfactory yields.