Journal of Medicinal Chemistry p. 368 - 372 (1980)
Update date:2022-08-25
Topics:
Wikel, J. H.
Paget, C. J.
DeLong, D. C.
Nelson, J. D.
Wu, C. Y. E.
et al.
The synthesis and antirhinovirus activity of syn and anti isomers of 6-<<(hydroxyimino)phenyl>methyl>-1-<(1-methylethyl)sulfonyl>-1H-benzimidazol-2-amine (4 and 5) are reported.The structural assignements of 4 and 5 are based upon 13C NMR spectra of both isomers and also X-ray analysis of 5.The anti-isomer 5 was more potent than the syn-isomer 4 when compared as an inhibitor of rhinovirus multiplication in vitro.Both isomers inhibited multiplication of 15 differrent serotypes of rhinovirus.
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