1074-40-4

Basic information

• Product Name: 2-Methoxy-4,6-dichloropyrimidine
• Synonyms: 2-methoxy-4,6-dichloropyrimidine;4,6-DICHLORO-2-METHOXY-PYRIMIDINE;Pyrimidine, 4,6-dichloro-2-methoxy-;4.6-DICHLORO-2-METHOXYPYRIMIDIN;2-Methoxy-4,6-dichloropyriMidinee;4,6-Dichloro-2-methoxy-1,3-diazine, 4,6-Dichloropyrimidin-2-yl methyl ether
• CAS NO: 1074-40-4
• Molecular Formula: C₅H₄Cl₂N₂O
• Molecular Weight: 179
• Product Categories: Heterocyclic Compounds;Heterocycles;Heterocycle-Pyrimidine series
• Mol File: 1074-40-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 59-60°C
• Boiling Point: 105°C (11 Torr)
• Flash Point: 119°C
• Appearance: Pale yellow solid
• Density: 1.446
• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.541
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform, Methanol
• PKA: -4.52±0.30(Predicted)
• CAS DataBase Reference: 2-Methoxy-4,6-dichloropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxy-4,6-dichloropyrimidine(1074-40-4)
• EPA Substance Registry System: 2-Methoxy-4,6-dichloropyrimidine(1074-40-4)

Safety Data

• Hazardous Substances Data: 1074-40-4(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

InChI:InChI=1/C5H4Cl2N2O/c1-10-5-8-3(6)2-4(7)9-5/h2H,1H3

Upstream product

• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 4489-34-3 4,6-dichloro-2-(methylsulfonyl)pyrimidine 
• 3764-01-0 2,4,6-trichloropyrimidine 
• 1758-98-1 2-methoxy-4,6-dihydroxy-pyrimidine 

Downstream Products

• 885068-32-6 (6-chloro-2-methoxy-pyrimidin-4-yl)-(2,2-difluoro-2-phenyl-ethyl)-amine 
• 885068-39-3 (6-chloro-2-methoxy-pyrimidin-4-yl)-[2-(3,4-difluoro-phenyl)-ethyl]-amine 
• 885066-01-3 (6-chloro-2-methoxy-pyrimidin-4-yl)-[2-(3-fluoro-4-methoxy-phenyl)-ethyl]-amine 
• 885067-45-8 (6-chloro-2-methoxy-pyrimidin-4-yl)-[2-(4-chloro-phenyl)-ethyl]-amine 
• 885066-11-5 (6-chloro-2-methoxy-pyrimidin-4-yl)-[2-(4-trifluoromethoxy-phenyl)-ethyl]-amine 
• 1365534-19-5 C₁₈H₁₃ClN₄O₃S 
• 885068-40-6 3-{6-[2-(3,4-difluoro-phenyl)-ethylamino]-2-methoxy-pyrimidin-4-yl}-phenol 
• 953080-29-0 5-(6-(2-(2,4-dichlorophenyl)ethylamino)-2-methoxy-pyrimidin-4-yl)-1-methyl-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester 

Relevant articles and documents

PIKFYVE KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) as well as their use for treating diseases and disorders associated with PIKfyve.

Aminopyrimidinone Cdc7 Kinase Inhibitors

We have investigated the SAR of a series of pyrimidinone-containing Cdc7 kinase inhibitors. A wide range of amine substitutions give potent compounds with activities (Ki) less than 1 nM. Kinase selectivity is reasonable and cytotoxicity corresponds to inhibition of MCM2 phosphorylation.

ANTIPROLIFERATIVE PYRIMIDYL, FUSED PYRIMIDYL AND PYRIMIDYL HYDRAZONES

The present invention is related to a novel series of pyrimidyl or fused pyrimidyl hydrazones. Compounds of Formula (I) wherein A is selected from the group consisting of Formulas (A1), (A2), (A3), (A4), (A5) are useful for the treatment and/or prevention of a proliferative disease.