6325-43-5

Usage

Uses

Used in Pain Management:
Flurbiprofen is utilized as an analgesic agent for the treatment of mild to moderate pain, including conditions such as arthritis, menstrual cramps, and dental pain. Its efficacy in pain relief is attributed to its ability to block the production of prostaglandins, which are natural substances that cause pain and inflammation.
Used in Anti-Inflammatory Applications:
In the anti-inflammatory domain, flurbiprofen serves as an effective NSAID, reducing inflammation by inhibiting the cyclooxygenase (COX) enzymes involved in the synthesis of prostaglandins. This action is particularly beneficial for conditions characterized by excessive inflammation, such as arthritis.
Used in Fever Reduction:
Flurbiprofen is employed as an antipyretic agent to lower fever by regulating the body's temperature set point, providing relief from the discomfort associated with elevated body temperatures.
Used in Ophthalmology:
In the field of ophthalmology, flurbiprofen is used as an ophthalmic solution for the treatment of eye inflammation. Its anti-inflammatory properties help alleviate symptoms such as redness, swelling, and discomfort in the eyes.
Used in Pharmaceutical Formulations:
Flurbiprofen is incorporated into various pharmaceutical formulations, including tablets, capsules, and ophthalmic solutions, to cater to different modes of administration and patient needs. This versatility in formulation allows for targeted treatment of specific conditions while minimizing systemic side effects.

InChI:InChI=1/C11H13NO3/c1-8(13)12-10-5-2-9(3-6-10)4-7-11(14)15/h2-3,5-6H,4,7H2,1H3,(H,12,13)(H,14,15)

Upstream product

• 67249-02-9 (E)-3-(4-acetylaminophenyl)acrylic acid 
• 2393-17-1 3-(4-aminophenyl)propionic acid 
• 108-24-7 acetic anhydride 
• 16642-79-8 3-(4-nitrophenyl)propionic acid 
• 124-38-9 carbon dioxide 
• 39232-06-9 2-bromo-1-[4-(acetylamino)phenyl]-ethane 
• 83345-11-3 N-[4-(2-hydroxylethyl)phenyl]acetamide 

Downstream Products

• 63630-08-0 N-[4-(2-aminoethyl)phenyl]acetamide 
• 54405-43-5 3-(4-acetylamino-3-nitro-phenyl)-propionic acid 
• 116836-08-9 3-(4-amino-3-bromo-phenyl)-propionic acid 

Relevant academic research and scientific papers

Site-Selective, Remote sp3 C?H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis

A photoinduced carboxylation of alkyl halides with CO2 at remote sp3 C?H sites enabled by the merger of photoredox and Ni catalysis is described. This protocol features a predictable reactivity and site selectivity that can be modulated by the ligand backbone. Preliminary studies reinforce a rationale based on a dynamic displacement of the catalyst throughout the alkyl side chain.

INDANYLAMINO URACILS AND THEIR USE AS ANTIOXIDANTS AND NEUROPROTECTANTS

Disclosed are compounds having the structure (I) wherein, R1 is H, NH2, NH-(C1-C4) alkyl, or N-[(C1-C4)alkyl]2; R2 and R3 are each independently H, (C1-C4) alkyl, or structure (II), wherein R4 is H, (C1-C4) alkyl, halogen, hydroxy, (C1-C10)alkoxy, cyano, nitro, -NR5R6, or -OCONR7R8; wherein R5 and R6 are each independently H, or a substituted or unsubstituted (C1-C4) alkyl; and wherein R7 and R8 are each independently H, or substituted or unsubstituted (C1-C4) alkyl or (C1-C10)aryl; and wherein only one of R2 and R3 is H, enantiomers, tautomers, and pharmaceutically acceptable salts of the compounds, pharmaceutical compositions containing such compounds or salts, and processes for their preparation. The subject invention also provides methods of alleviating symptoms of neurologic and inflammatory disorders, methods of preventing oxidation of lipids, proteins, or deoxyribonucleic acids on a cellular level, and methods of protecting human red blood cells from lysis by O2 radicals.

Pyridopyrimidones, quinolines and fused N-heterocycles as bradykinin antagonists

This invention relates to a compound of the formula: STR1 wherein Z is a group of the formula: STR2 in which X1 is N or C--R1, X2 is N or C--R9, X3 is N or C--R2, R1 is lower alk