83345-11-3

Basic information

• Product Name: CHEMBRDG-BB 5529572
• Synonyms: CHEMBRDG-BB 5529572;N-[4-(2-HYDROXYETHYL)PHENYL]ACETAMIDE;N-[4-(2-hydroxyethyl)phenyl]acetamide(SALTDATA: FREE);THYL)PHENYL]ACETAMIDE
• CAS NO: 83345-11-3
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Mol File: 83345-11-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 395.6°C at 760 mmHg
• Flash Point: 193.1°C
• Appearance: /
• Density: 1.172g/cm³
• Vapor Pressure: 5.71E-07mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: CHEMBRDG-BB 5529572(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMBRDG-BB 5529572(83345-11-3)
• EPA Substance Registry System: CHEMBRDG-BB 5529572(83345-11-3)

Safety Data

• Hazardous Substances Data: 83345-11-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H13NO2/c1-8(13)11-10-4-2-9(3-5-10)6-7-12/h2-5,12H,6-7H2,1H3,(H,11,13)

Upstream product

• 100-27-6 2-(4-nitrophenyl)ethanol 
• 102494-22-4 1-[4-(2-hydroxyethyl)phenyl]ethanone oxime 
• 75178-16-4 2-(4-Acetamidophenyl)ethyl acetate 
• 108-24-7 acetic anhydride 
• 104-10-9 2-(4'-aminophenyl)ethyl alcohol 

Downstream Products

• 1108732-86-0 6-[[2-(4-acetylaminophenyl)ethoxy](4-nitrophenoxy)phosphoryl]hexanoic acid 2-(toluene-4-sulfonyl)ethyl ester 
• 1108732-92-8 propionic acid 2-(4-acetylaminophenyl)ethyl ester 
• 1108732-89-3 toluene-4-sulfonic acid 2-(4-acethylaminophenyl)ethyl ester 
• 100-02-7 4-nitro-phenol 
• 39232-06-9 2-bromo-1-[4-(acetylamino)phenyl]-ethane 
• 75178-16-4 2-(4-Acetamidophenyl)ethyl acetate 
• 1085309-04-1 (p-acetylamino)phenylacetaldehyde 

Relevant articles and documents

ADENOSINE RECEPTOR BINDING COMPOUNDS

The present invention relates to pharmaceutical compounds and compositions of Formula (I) and methods of treatment using the compounds and compositions, especially for the treatment and/or prevention of a proliferation disorder, such as cancer. Compounds of Formula (I) as further described herein are shown modulators of the adenosine A2A receptor and exhibit antiproliferative activity. Accordingly, these compounds are useful to treat proliferative disorders such as cancer, and other adenosine receptor-related conditions including an inflammatory disease, renal disease, diabetes, vascular disease, lung disease, or an autoimmune disease.

A one-pot process for palladium catalyzed direct C-H acylation of anilines in water using a removable ortho directing group

A new mild, practical method for the synthesis of aminobenzophenone derivatives through a three step one-pot reaction sequence involving acylation of anilines, palladium catalyzed cross-dehydrogenative coupling of the formed anilides and the hydrolytic cleavage is reported. The full reaction sequence was performed under aqueous conditions.

Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma

We have previously reported substituted 2-aryl-thiazolidine-4-carboxylic acid amides as potent and selective antiproliferative agents for melanoma. To understand the importance of the thiazolidine ring and to reduce potential complications associated with the two chiral centers, we designed and synthesized sets of new analogs by modifying this ring. These new analogs were tested in two melanoma cell lines and fibroblast cells (negative controls). Compared with the older analogs containing the thiazolidine ring, these new analogs have lower potency in general, but some of these analogs still have very good selectivity. These structure-activity studies indicated that the thiazolidine ring is very critical for the activity for these series of compounds.