63250-31-7

Basic information

• Product Name: 1-(3-sulfanylpropanoyl)-L-proline
• Synonyms: 1-(3-Sulfanylpropanoyl)-L-proline; L-proline, 1-(3-mercapto-1-oxopropyl)-
• CAS NO: 63250-31-7
• Molecular Formula: C₈H₁₃NO₃S
• Molecular Weight: 203.2587
• Mol File: 63250-31-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 431.1°C at 760 mmHg
• Flash Point: 214.5°C
• Density: 1.321g/cm³
• Vapor Pressure: 1.22E-08mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 1-(3-sulfanylpropanoyl)-L-proline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-sulfanylpropanoyl)-L-proline(63250-31-7)
• EPA Substance Registry System: 1-(3-sulfanylpropanoyl)-L-proline(63250-31-7)

Safety Data

• Hazardous Substances Data: 63250-31-7(Hazardous Substances Data)

Usage

General Description

1-(3-sulfanylpropanoyl)-L-proline is a chemical compound with the molecular formula C8H15NO3S. It is a derivative of proline and contains a sulfanylpropanoyl group. 1-(3-sulfanylpropanoyl)-L-proline has potential therapeutic properties and is being studied for its anti-inflammatory and antioxidant effects. It is also being investigated for its potential role in treating cardiovascular diseases and cancer. The compound has been shown to inhibit the activity of certain enzymes involved in inflammatory processes and to scavenge free radicals, which can cause damage to cells and tissues. Overall, 1-(3-sulfanylpropanoyl)-L-proline shows promise as a potential drug candidate for various medical conditions.

Upstream product

• 1336-21-6 ammonium hydroxide 
• 64805-52-3 1-(3-benzoylthiopropanoyl)-L-proline 
• 107-96-0 3-mercaptopropionic acid 
• 147-85-3 L-proline 

Downstream Products

• 64805-99-8 1-[3-[(4-Methylphenyl)dithio]propanoyl]-L-Proline 

Relevant articles and documents

Repurposing the 3-Isocyanobutanoic Acid Adenylation Enzyme SfaB for Versatile Amidation and Thioesterification

Genome mining of microbial natural products enables chemists not only to discover the bioactive molecules with novel skeletons, but also to identify the enzymes that catalyze diverse chemical reactions. Exploring the substrate promiscuity and catalytic mechanism of those biosynthetic enzymes facilitates the development of potential biocatalysts. SfaB is an acyl adenylate-forming enzyme that adenylates a unique building block, 3-isocyanobutanoic acid, in the biosynthetic pathway of the diisonitrile natural product SF2768 produced by Streptomyces thioluteus, and this AMP-ligase was demonstrated to accept a broad range of short-chain fatty acids (SCFAs). Herein, we repurpose SfaB to catalyze amidation or thioesterification between those SCFAs and various amine or thiol nucleophiles, thereby providing an alternative enzymatic approach to prepare the corresponding amides and thioesters in vitro.

ORALLY EFFECTIVE ANTI-HYPERTENSIVE AGENTS

Novel thiolester compounds are disclosed which are orally effective angiotensin converting enzyme inhibitors useful in the treatment of mammalian hypertension. They have the formula, EQU1 wherein Z denotes-B-A 2, R 1 is H or an acyl group, A 1 is a carboxylic acid containing at least one amino or imino-N-, A 2 is a carboxylic acid containing at least one amino or imino-N-or a lower alkyl ester or amide thereof, B is a 2-4 carbon backbone chain in mercapto linkage to S which includes a carbonyl or sulfonyl group joined in carboxamido or sulfonamido linkage, respectively, to A 2. Preferably A 2 includes a 4-6 membered C-N ring or a 5 membered ring of one N, one S and 3 C atoms.

PROLINE DERIVATIVES AND RELATED COMPOUNDS

New proline derivatives and related compounds which have the general formula STR1 are useful as angiotensin converting enzyme inhibitors.