6334-42-5

Usage

InChI:InChI=1/C11H8N4O/c16-11-9-10(12-6-13-11)15(7-14-9)8-4-2-1-3-5-8/h1-7H,(H,12,13,16)

Upstream product

• 64-18-6 formic acid 
• 41259-65-8 6-chloro-N₄-phenylpyrimidine-4,5-diamine 
• 77287-34-4 formamide 
• 64995-55-7 1-phenyl-5-aminoimidazole-4-carboxamide 
• 68-12-2 N,N-dimethyl-formamide 
• 19158-51-1 P-toluenesulfonyl cyanide 
• 66950-63-8 phenyl N,N-dimethylsulfamate 
• 68-94-0 hypoxanthine 
• 65009-00-9 O-phenyl N,N-diethylcarbamate 
• 108-95-2 phenol 
• 591-50-4 iodobenzene 
• 68-94-0 1,7-dihydro-6H-purin-6-one 
• 108-86-1 bromobenzene 
• 62-53-3 aniline 

Downstream Products

• 5470-24-6 6-Chloro-9-phenyl-9H-purine 
• 21314-09-0 1,9-dihydro-9-phenyl-6H-purine-6-thione 

Relevant academic research and scientific papers

N -Arylation of (hetero)arylamines using aryl sulfamates and carbamates via C-O bond activation enabled by a reusable and durable nickel(0) catalyst

An effective and general aryl amination protocol has been developed using a magnetically recoverable Ni(0) based nanocatalyst. This new stable catalyst was prepared on Fe3O4@SiO2 modified by EDTA and investigated by FT-IR, EDX, TEM, XRD, DLS, FE-SEM, XPS, NMR, TGA, VSM, ICP and elemental analysis techniques. The reaction proceeded via carbon-oxygen bond cleavage of (hetero)aryl carbamates and sulfamates under simple and mild conditions without the use of any external ligands. This method demonstrated functional group tolerance in the N-arylation of various nitrogen-containing compounds as well as aliphatic amines, anilines, pyrroles, pyrazoles, imidazoles, indoles, and indazoles with good to excellent yields. Furthermore, the catalyst could be easily recovered by using an external magnetic field and directly reused at least six times without notable reduction in its activity. This journal is

PIPERIDINE DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7

The present invention concerns the identification of inhibitors of ubiquitin specific protease 7 (USP7), and methods of use thereof.

Direct N9-arylation of purines with aryl halides

An efficient method for N-arylation of purines is reported. The N-arylation is catalysed by Cu(i) and 4,7-bis(2-hydroxyethylamino)-1,10-phenanthroline (BHPhen) in aqueous DMF or ethanol. The reaction generally proceeds with high selectivity for the N

Electrophilic cyanations. I. Synthesis of thiocyanato-heteroarenes and tosylheteroarenes from mercapto-heteroarenes using p-toluenesulfonyl cyanide

Mercaptoheteroarenes (1) underwent electrophilic cyanation with p-toluenesulfonyl cyanide (TsCN) in THF in the presence of NaH to give the corresponding thiocyanatoheteroarenes (2) in moderate to good yields. In DMF, tosylheteroarenes (4) were formed by substitution with p-toluenesulfinate ion through thiocyanatoheteroarenes (2).

SYNTHESIS OF CROWN-CONTAINING XANTHINE DERIVATIVES

A number of new derivatives of xanthine, hypoxanthine, theophylline, and theobromine containing crown-ether substituents at the nitrogen atoms of the imidazole or pyrimidine nucleus was synthesized.

ETHYL CHLOROFORMATE/DMF IN ORGANIC SYNTHESIS. I. A NOVEL REAGENT FOR RING CLOSURE OF 5-AMINO-1-ARYL-4-IMIDAZOLECARBOXAMIDES TO THEIR HYPOXANTHINE DERIVATIVES

Ethyl chloroformate/dimethylformamide mixture is used as a new reagent for adding a carbon (C-2 in the purine nucleus) at the formic acid oxidation level during ring closure of 5-amino-1-aryl-4-imidazolecarboxamides leading to the formation of the corresp