6337-25-3

Usage

Uses

Used in Organic Synthesis:
(NZ)-N-[1-(4-phenoxyphenyl)ethylidene]hydroxylamine is used as a reagent in organic synthesis for the preparation of various organic compounds. Its unique structure allows it to participate in a wide range of chemical reactions, making it a valuable tool in the synthesis of complex molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (NZ)-N-[1-(4-phenoxyphenyl)ethylidene]hydroxylamine is utilized as a pharmaceutical intermediate. Its reactivity and structural properties make it a suitable candidate for the development of new drugs and medicinal compounds.
Used in Dye Production:
(NZ)-N-[1-(4-phenoxyphenyl)ethylidene]hydroxylamine also finds application in the production of some dyes. Its chemical properties contribute to the color and stability of the dyes, making it an important component in the dye manufacturing process.
Used in Medicinal Chemistry Research:
Due to its unique structure and reactivity, (NZ)-N-[1-(4-phenoxyphenyl)ethylidene]hydroxylamine has potential applications in the field of medicinal chemistry. Researchers can explore its properties to develop new compounds with therapeutic potential or to enhance the properties of existing drugs.

InChI:InChI=1/C14H13NO2/c1-11(15-16)12-7-9-14(10-8-12)17-13-5-3-2-4-6-13/h2-10,16H,1H3/b15-11+

Upstream product

• 5031-78-7 4-phenoxyacetophenone 
• 101-84-8 diphenylether 
• 108-90-7 chlorobenzene 

Downstream Products

• 102077-19-0 1-(4-phenoxyphenyl)ethylamine 
• 6312-87-4 p-phenoxyacetanilide 
• 115513-99-0 N-Hydroxy-N-[1-(4-phenoxy-phenyl)-ethyl]-acetamide 
• 315248-48-7 N-acetyl-sulfanilic acid-(4-phenoxy-anilide) 
• 139-59-3 4-phenoxyanilin 
• 100-19-6 (4-nitrophenyl)ethanone 
• 10342-64-0 p-nitroacetophenone oxime 
• 5031-78-7 4-phenoxyacetophenone 

Relevant academic research and scientific papers

Design, synthesis, herbicidal activity, and the molecular docking study of novel diphenyl ether derivatives as protoporphyrinogen IX oxidase inhibitors

Protoporphyrinogen oxidase (PPO, EC 1.3.3.4) is an important herbicide target. In this study, a series of novel diphenyl ethers derivatives with 2-pyrrolidone structure were developed as PPO inhibitors. Thereinto, compound H7 (IC50 = 0.0262 mg/L) has better PPO enzyme inhibitory activity than commercial herbicide oxyfluorfen (IC50 = 0.0426 mg/L). Greenhouse herbicidal activity experiments exhibited that even under the condition of 37.5 g ai/ha, H7 still had excellent broad-spectrum herbicidal activity. Moreover, rice, peanut, and cotton had strong tolerance to H7 at 300 g ai/ha. Field trial showed that H7 had comparable herbicidal activity to oxyfluorfen. These experimental results indicated that H7 could be developed as a novel PPO Inhibitor candidate for weed control in the field.

Dehydrative Beckmann rearrangement and the following cascade reactions

The Beckmann rearrangement has been predominantly studied for the synthesis of amide and lactam. By strategically using the in situ generated Appel's salt or Mitsunobu's zwitterionic adduct as the dehydrating agent, a series of Beckmann rearrangement and following cascade reactions have been developed herein. The protocol allows the conversion of various ketoximes into amide, thioamide, tetrazole and imide products in modular procedures. The generality and tolerance of functionalities of this method have been demonstrated.

Facile preparation of 5-alkyl-1-aryltetrazoles with arenes, acyl chlorides, hydroxylamine, and diphenylphosphoryl azide

Successive treatment of arenes with acyl chlorides and AlCl3, the addition of water and removal of solvent, the reaction with NH2OH?HCl and K2CO3, and the reaction with diphenylphosphoryl azide and DBU under warming conditions gave the corresponding 5-alkyl-1-aryltetrazoles efficiently in good to moderate yields. The present method is one-pot transformation of arenes into 5-alkyl-1-aryltetrazoles using the Friedel-Crafts acylation and the Beckmann rearrangement under transition-metal-free conditions.

Structure-activity analysis of a class of orally active hydroxamic acid inhibitors of leukotriene biosynthesis

The nature of the carbonyl and nitrogen substituents of hydroxamic acids has a major influence on the biological profile of these compounds. Hydroxamates with small groups such as methyl appended to the carbonyl and relatively large nitrogen substituents